Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Overview of the Alliance for Cellular Signaling.
Authors: Authors: Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR.
Nature
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Hitting the target: emerging technologies in the search for kinase substrates.
Authors: Authors: Manning BD, Cantley LC.
Sci STKE
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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
Authors: Authors: Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J.
Proc Natl Acad Sci U S A
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Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26.
Authors: Authors: Park HI, Turk BE, Gerkema FE, Cantley LC, Sang QX.
J Biol Chem
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An integrated vector system for cellular studies of phage display-derived peptides.
Authors: Authors: Voss SD, DeGrand AM, Romeo GR, Cantley LC, Frangioni JV.
Anal Biochem
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A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity.
Authors: Authors: Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR.
Nat Cell Biol
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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.
Authors: Authors: Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC.
Mol Cell
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The phosphoinositide 3-kinase pathway.
Authors: Authors: Cantley LC.
Science
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Lipid research picks up speed on the slopes of Taos.
Authors: Authors: Field SJ, Lamia KA, Rameh LE, Cantley LC.
Dev Cell
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Akt/protein kinase B promotes organ growth in transgenic mice.
Authors: Authors: Shioi T, McMullen JR, Kang PM, Douglas PS, Obata T, Franke TF, Cantley LC, Izumo S.
Mol Cell Biol
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