Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation.
Authors: Authors: Woolsey AM, Sunwoo L, Petersen CA, Brachmann SM, Cantley LC, Burleigh BA.
J Cell Sci
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The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation.
Authors: Authors: Carricaburu V, Lamia KA, Lo E, Favereaux L, Payrastre B, Cantley LC, Rameh LE.
Proc Natl Acad Sci U S A
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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
Authors: Authors: Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J.
Curr Biol
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Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions.
Authors: Authors: Katome T, Obata T, Matsushima R, Masuyama N, Cantley LC, Gotoh Y, Kishi K, Shiota H, Ebina Y.
J Biol Chem
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The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.
Authors: Authors: Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J.
Cell
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Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs.
Authors: Authors: Obenauer JC, Cantley LC, Yaffe MB.
Nucleic Acids Res
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United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling.
Authors: Authors: Manning BD, Cantley LC.
Biochem Soc Trans
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Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.
Authors: Authors: Elia AE, Cantley LC, Yaffe MB.
Science
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Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha.
Authors: Authors: Hallmann D, Trümper K, Trusheim H, Ueki K, Kahn CR, Cantley LC, Fruman DA, Hörsch D.
J Biol Chem
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Peptide libraries: at the crossroads of proteomics and bioinformatics.
Authors: Authors: Turk BE, Cantley LC.
Curr Opin Chem Biol
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