Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Identification and characterization of a phosphoinositide phosphate kinase homolog.
Authors: Authors: Chang JD, Field SJ, Rameh LE, Carpenter CL, Cantley LC.
J Biol Chem
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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Authors: Authors: Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.
Proc Natl Acad Sci U S A
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ZIP codes for delivering SH2 domains.
Authors: Authors: Songyang Z, Cantley LC.
Cell
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Identification of small molecule inhibitors of anthrax lethal factor.
Authors: Authors: Panchal RG, Hermone AR, Nguyen TL, Wong TY, Schwarzenbacher R, Schmidt J, Lane D, McGrath C, Turk BE, Burnett J, Aman MJ, Little S, Sausville EA, Zaharevitz DW, Cantley LC, Liddington RC, Gussio R, Bavari S.
Nat Struct Mol Biol
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The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Authors: Authors: Turk BE, Wong TY, Schwarzenbacher R, Jarrell ET, Leppla SH, Collier RJ, Liddington RC, Cantley LC.
Nat Struct Mol Biol
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Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi.
Authors: Authors: Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J.
J Biol Chem
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Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling.
Authors: Authors: Ueki K, Fruman DA, Yballe CM, Fasshauer M, Klein J, Asano T, Cantley LC, Kahn CR.
J Biol Chem
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Rheb fills a GAP between TSC and TOR.
Authors: Authors: Manning BD, Cantley LC.
Trends Biochem Sci
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The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.
Authors: Authors: Elia AE, Rellos P, Haire LF, Chao JW, Ivins FJ, Hoepker K, Mohammad D, Cantley LC, Smerdon SJ, Yaffe MB.
Cell
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Targeting the PI3K-Akt pathway in human cancer: rationale and promise.
Authors: Authors: Luo J, Manning BD, Cantley LC.
Cancer Cell
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