Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Synthesis and activity of C11-modified wortmannin probes for PI3 kinase.
Authors: Authors: Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L.
Bioconjug Chem
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The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO.
Authors: Authors: Abbott DW, Wilkins A, Asara JM, Cantley LC.
Curr Biol
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A rapid method for determining protein kinase phosphorylation specificity.
Authors: Authors: Hutti JE, Jarrell ET, Chang JD, Abbott DW, Storz P, Toker A, Cantley LC, Turk BE.
Nat Methods
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A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms.
Authors: Authors: Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A.
J Biol Chem
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Large-scale characterization of HeLa cell nuclear phosphoproteins.
Authors: Authors: Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP.
Proc Natl Acad Sci U S A
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A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.
Authors: Authors: Mitra P, Zhang Y, Rameh LE, Ivshina MP, McCollum D, Nunnari JJ, Hendricks GM, Kerr ML, Field SJ, Cantley LC, Ross AH.
J Cell Biol
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The LKB1 tumor suppressor negatively regulates mTOR signaling.
Authors: Authors: Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC.
Cancer Cell
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Differential regulation of the phosphoinositide 3-kinase and MAP kinase pathways by hepatocyte growth factor vs. insulin-like growth factor-I in myogenic cells.
Authors: Authors: Halevy O, Cantley LC.
Exp Cell Res
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Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice.
Authors: Authors: Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB, Cantley LC.
Mol Cell Biol
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Using peptide libraries to identify optimal cleavage motifs for proteolytic enzymes.
Authors: Authors: Turk BE, Cantley LC.
Methods
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