Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex.
Authors: Authors: Luo J, Field SJ, Lee JY, Engelman JA, Cantley LC.
J Cell Biol
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Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase.
Authors: Authors: Luo J, Sobkiw CL, Logsdon NM, Watt JM, Signoretti S, O'Connell F, Shin E, Shim Y, Pao L, Neel BG, Depinho RA, Loda M, Cantley LC.
Proc Natl Acad Sci U S A
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The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.
Authors: Authors: Kang CM, Abbott DW, Park ST, Dascher CC, Cantley LC, Husson RN.
Genes Dev
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Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation.
Authors: Authors: Park J, Hu Y, Murthy TV, Vannberg F, Shen B, Rolfs A, Hutti JE, Cantley LC, Labaer J, Harlow E, Brizuela L.
Proc Natl Acad Sci U S A
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The C2 domain of PKCdelta is a phosphotyrosine binding domain.
Authors: Authors: Benes CH, Wu N, Elia AE, Dharia T, Cantley LC, Soltoff SP.
Cell
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DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.
Authors: Authors: Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD.
J Biol Chem
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Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement.
Authors: Authors: Brachmann SM, Yballe CM, Innocenti M, Deane JA, Fruman DA, Thomas SM, Cantley LC.
Mol Cell Biol
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ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines.
Authors: Authors: Engelman JA, Jänne PA, Mermel C, Pearlberg J, Mukohara T, Fleet C, Cichowski K, Johnson BE, Cantley LC.
Proc Natl Acad Sci U S A
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Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.
Authors: Authors: Brachmann SM, Ueki K, Engelman JA, Kahn RC, Cantley LC.
Mol Cell Biol
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Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms.
Authors: Authors: Gozani O, Field SJ, Ferguson CG, Ewalt M, Mahlke C, Cantley LC, Prestwich GD, Yuan J.
Adv Enzyme Regul
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