Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513

240 Longwood Avenue

Boston, MA 02115

Interaction between the Rous sarcoma virus transforming protein and two cellular phosphoproteins: analysis of the turnover and distribution of this complex.
Authors: Authors: Brugge J, Yonemoto W, Darrow D.
Mol Cell Biol
View full abstract on Pubmed
A major cytoplasmic glucose-regulated protein is associated with the Rous sarcoma virus pp60src protein.
Authors: Authors: Lanks KW, Kasambalides EJ, Chinkers M, Brugge JS.
J Biol Chem
View full abstract on Pubmed
Association of the transforming proteins of Rous, Fujinami, and Y73 avian sarcoma viruses with the same two cellular proteins.
Authors: Authors: Lipsich LA, Cutt JR, Brugge JS.
Mol Cell Biol
View full abstract on Pubmed
Rous sarcoma virus-induced phosphorylation of a 50,000-molecular weight cellular protein.
Authors: Authors: Brugge JS, Darrow D.
Nature
View full abstract on Pubmed
The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins.
Authors: Authors: Brugge JS, Erikson E, Erikson RL.
Cell
View full abstract on Pubmed
Molecular events in cells transformed by Rous Sarcoma virus.
Authors: Authors: Erikson RL, Purchio AF, Erikson E, Collett MS, Brugge JS.
J Cell Biol
View full abstract on Pubmed
Transforming gene product of avian sarcoma viruses and its homolog in uninfected cells.
Authors: Authors: Erikson RL, Collett MS, Erikson E, Purchio AF, Brugge JS.
Prog Clin Biol Res
View full abstract on Pubmed
Protein phosphorylation mediated by partially purified avian sarcoma virus transforming-gene product.
Authors: Authors: Erikson RI, Collett MS, Erikson E, Purchio AF, Brugge JS.
Cold Spring Harb Symp Quant Biol
View full abstract on Pubmed
Expression of the src-gene product, pp60src, in transformed and reverted mammalian cells infected with avian sarcoma virus.
Authors: Authors: Lau AF, Krzyzek RA, Brugge JS, Collett MS, Erikson RL, Faras AJ.
Cold Spring Harb Symp Quant Biol
View full abstract on Pubmed
The src gene product of transformed and morphologically reverted ASV-infected mammalian cells.
Authors: Authors: Collett MS, Brugge JS, Erikson RL, Lau AF, Krzyzek RA, Faras AJ.
Nature
View full abstract on Pubmed