Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513

240 Longwood Avenue

Boston, MA 02115

Tyrosine phosphorylation within the amino-terminal domain of pp60c-src molecules associated with polyoma virus middle-sized tumor antigen.
Authors: Authors: Yonemoto W, Jarvis-Morar M, Brugge JS, Bolen JB, Israel MA.
Proc Natl Acad Sci U S A
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Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation.
Authors: Authors: Bolen JB, Thiele CJ, Israel MA, Yonemoto W, Lipsich LA, Brugge JS.
Cell
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Characterization of structural domains of the human epidermal growth factor receptor obtained by partial proteolysis.
Authors: Authors: Chinkers M, Brugge JS.
J Biol Chem
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Mutation of a termination codon affects src initiation.
Authors: Authors: Hughes S, Mellstrom K, Kosik E, Tamanoi F, Brugge J.
Mol Cell Biol
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Expression of the Rous sarcoma virus src gene in avian macrophages fails to elicit transformed cell phenotype.
Authors: Authors: Lipsich L, Brugge JS, Boettiger D.
Mol Cell Biol
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Differentiation and transformation of neural plate cells.
Authors: Authors: Keane RW, Lipsich LA, Brugge JS.
Dev Biol
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Analysis of the catalytic domain of phosphotransferase activity of two avian sarcoma virus-transforming proteins.
Authors: Authors: Brugge JS, Darrow D.
J Biol Chem
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Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses.
Authors: Authors: Lipsich LA, Lewis AJ, Brugge JS.
J Virol
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Neural tissues express high levels of the cellular src gene product pp60c-src.
Authors: Authors: Cotton PC, Brugge JS.
Mol Cell Biol
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Interaction between the Rous sarcoma virus transforming protein and two cellular phosphoproteins: analysis of the turnover and distribution of this complex.
Authors: Authors: Brugge J, Yonemoto W, Darrow D.
Mol Cell Biol
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