Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513

240 Longwood Avenue

Boston, MA 02115

Characterization of the altered form of the c-src gene product in neuronal cells.
Authors: Authors: Brugge J, Cotton P, Lustig A, Yonemoto W, Lipsich L, Coussens P, Barrett JN, Nonner D, Keane RW.
Genes Dev
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Detection of phosphotyrosine-containing proteins in polyomavirus middle tumor antigen-transformed cells after treatment with a phosphotyrosine phosphatase inhibitor.
Authors: Authors: Yonemoto W, Filson AJ, Queral-Lustig AE, Wang JY, Brugge JS.
Mol Cell Biol
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Changes in the pattern of expression of pp60c-src in cerebellar mutants of mice.
Authors: Authors: Brugge JS, Lustig A, Messer A.
J Neurosci Res
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Induction of altered c-src product during neural differentiation of embryonal carcinoma cells.
Authors: Authors: Lynch SA, Brugge JS, Levine JM.
Science
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The p35/p36 substrates of protein-tyrosine kinases as inhibitors of phospholipase A2.
Authors: Authors: Brugge JS.
Cell
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Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.
Authors: Authors: Golden A, Nemeth SP, Brugge JS.
Proc Natl Acad Sci U S A
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Investigations of the expression of the cellular src gene product.
Authors: Authors: Brugge JS, Yonemoto W, Lustig A, Golden A.
Princess Takamatsu Symp
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Interaction of the Rous sarcoma virus protein pp60src with the cellular proteins pp50 and pp90.
Authors: Authors: Brugge JS.
Curr Top Microbiol Immunol
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A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src.
Authors: Authors: Schuh S, Yonemoto W, Brugge J, Bauer VJ, Riehl RM, Sullivan WP, Toft DO.
J Biol Chem
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Neurones express high levels of a structurally modified, activated form of pp60c-src.
Authors: Authors: Brugge JS, Cotton PC, Queral AE, Barrett JN, Nonner D, Keane RW.
Nature
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