Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513

240 Longwood Avenue

Boston, MA 02115

Immunocytochemical localization of the neuron-specific form of the c-src gene product, pp60c-src(+), in rat brain.
Authors: Authors: Sugrue MM, Brugge JS, Marshak DR, Greengard P, Gustafson EL.
J Neurosci
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Analysis of mutant forms of the c-src gene product containing a phenylalanine substitution for tyrosine 416.
Authors: Authors: Ferracini R, Brugge J.
Oncogene Res
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Biological and biochemical properties of the c-src+ gene product overexpressed in chicken embryo fibroblasts.
Authors: Authors: Levy JB, Brugge JS.
Mol Cell Biol
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Deletions within the amino-terminal half of the c-src gene product that alter the functional activity of the protein.
Authors: Authors: Nemeth SP, Fox LG, DeMarco M, Brugge JS.
Mol Cell Biol
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Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.
Authors: Authors: Golden A, Brugge JS.
Proc Natl Acad Sci U S A
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Widespread distribution of the c-src gene product in nerve cells and axon terminals in the adult rat brain.
Authors: Authors: Walaas SI, Lustig A, Greengard P, Brugge JS.
Brain Res
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Investigation of factors that influence phosphorylation of pp60c-src on tyrosine 527.
Authors: Authors: Schuh SM, Brugge JS.
Mol Cell Biol
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Phenotypic and genetic alterations in pre-cancerous cells in the colon.
Authors: Authors: Lundy J, Chen J, Wang P, Fromowitz F, Schuss A, Lynch S, Brugge J, Viola MV.
Anticancer Res
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The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA.
Authors: Authors: Levy JB, Dorai T, Wang LH, Brugge JS.
Mol Cell Biol
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Expression of Rous sarcoma virus transforming protein pp60v-src in Saccharomyces cerevisiae cells.
Authors: Authors: Brugge JS, Jarosik G, Andersen J, Queral-Lustig A, Fedor-Chaiken M, Broach JR.
Mol Cell Biol
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