Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513

240 Longwood Avenue

Boston, MA 02115

Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions.
Authors: Authors: Weng Z, Rickles RJ, Feng S, Richard S, Shaw AS, Schreiber SL, Brugge JS.
Mol Cell Biol
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Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation.
Authors: Authors: Mukhopadhyay D, Tsiokas L, Zhou XM, Foster D, Brugge JS, Sukhatme VP.
Nature
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Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE.
Authors: Authors: Shiue L, Zoller MJ, Brugge JS.
J Biol Chem
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Integrins and signal transduction pathways: the road taken.
Authors: Authors: Clark EA, Brugge JS.
Science
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Clustering of Syk is sufficient to induce tyrosine phosphorylation and release of allergic mediators from rat basophilic leukemia cells.
Authors: Authors: Rivera VM, Brugge JS.
Mol Cell Biol
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Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries.
Authors: Authors: Rickles RJ, Botfield MC, Weng Z, Taylor JA, Green OM, Brugge JS, Zoller MJ.
EMBO J
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Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3.
Authors: Authors: Clark EA, Shattil SJ, Ginsberg MH, Bolen J, Brugge JS.
J Biol Chem
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Regulation of protein tyrosine kinases in platelets.
Authors: Authors: Clark EA, Shattil SJ, Brugge JS.
Trends Biochem Sci
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Adhesive signaling in platelets.
Authors: Authors: Shattil SJ, Ginsberg MH, Brugge JS.
Curr Opin Cell Biol
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Structurally distinct disintegrins contortrostatin and multisquamatin differentially regulate platelet tyrosine phosphorylation.
Authors: Authors: Clark EA, Trikha M, Markland FS, Brugge JS.
J Biol Chem
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