Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513

240 Longwood Avenue

Boston, MA 02115

Casting light on focal adhesions.
Authors: Authors: Brugge JS.
Nat Genet
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Integrin-mediated signals regulated by members of the rho family of GTPases.
Authors: Authors: Clark EA, King WG, Brugge JS, Symons M, Hynes RO.
J Cell Biol
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Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3.
Authors: Authors: Gao J, Zoller KE, Ginsberg MH, Brugge JS, Shattil SJ.
EMBO J
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Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation.
Authors: Authors: King WG, Mattaliano MD, Chan TO, Tsichlis PN, Brugge JS.
Mol Cell Biol
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Protein tyrosine kinases Syk and ZAP-70 display distinct requirements for Src family kinases in immune response receptor signal transduction.
Authors: Authors: Zoller KE, MacNeil IA, Brugge JS.
J Immunol
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Cellular functions regulated by Src family kinases.
Authors: Authors: Thomas SM, Brugge JS.
Annu Rev Cell Dev Biol
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Leukocyte protein tyrosine kinases: potential targets for drug discovery.
Authors: Authors: Bolen JB, Brugge JS.
Annu Rev Immunol
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Thrombin receptor activation and integrin engagement stimulate tyrosine phosphorylation of the proto-oncogene product, p95vav, in platelets.
Authors: Authors: Cichowski K, Brugge JS, Brass LF.
J Biol Chem
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Calcium influx induces neurite growth through a Src-Ras signaling cassette.
Authors: Authors: Rusanescu G, Qi H, Thomas SM, Brugge JS, Halegoua S.
Neuron
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Phage display selection of ligand residues important for Src homology 3 domain binding specificity.
Authors: Authors: Rickles RJ, Botfield MC, Zhou XM, Henry PA, Brugge JS, Zoller MJ.
Proc Natl Acad Sci U S A
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