Headshot of Ed Chouchani

Edward Chouchani, Ph.D.

Professor of Cancer Biology (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
HHMI Investigator

Edward Chouchani, Ph.D., joined the faculty of Harvard Medical School in 2017. He received his Ph.D. in Biological Sciences at the University of Cambridge and MRC Mitochondrial Biology Unit. He then performed postdoctoral research at the Dana-Farber Cancer Institute and Harvard Medical School. In 2024, he became a Howard Hughes Medical Institute Investigator.

Research in the Chouchani Lab focuses on deciphering molecular mechanisms that drive metabolic disease, and using this information to develop targeted therapeutic strategies.  Mitochondria are critical hubs for metabolic signaling, and their dysfunction is key in the pathology of metabolic disease.  The Chouchani Lab combines mass spectrometry and targeted pharmacological approaches in vivo to understand how mitochondrial redox metabolism controls physiology in clinically informative mouse models of obesity and diabetes.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6212

360 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-632-3281

Lab Fax: 617-632-5363

H+ transport is an integral function of the mitochondrial ADP/ATP carrier.
Authors: Authors: Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace DC, Spiegelman BM, Kirichok Y.
Nature
View full abstract on Pubmed
Metabolic adaptation and maladaptation in adipose tissue.
Authors: Authors: Chouchani ET, Kajimura S.
Nat Metab
View full abstract on Pubmed
New Advances in Adaptive Thermogenesis: UCP1 and Beyond.
Authors: Authors: Chouchani ET, Kazak L, Spiegelman BM.
Cell Metab
View full abstract on Pubmed
Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity.
Authors: Authors: Kazak L, Rahbani JF, Samborska B, Lu GZ, Jedrychowski MP, Lajoie M, Zhang S, Ramsay LC, Dou FY, Tenen D, Chouchani ET, Dzeja P, Watson IR, Tsai L, Rosen ED, Spiegelman BM.
Nat Metab
View full abstract on Pubmed
Coupling Krebs cycle metabolites to signalling in immunity and cancer.
Authors: Authors: Ryan DG, Murphy MP, Frezza C, Prag HA, Chouchani ET, O'Neill LA, Mills EL.
Nat Metab
View full abstract on Pubmed
Mechanisms of Mitochondria Assembly, Dynamics and Turnover in Health and Disease.
Authors: Authors: Chouchani ET, Liesa M, Trifunovic A.
J Mol Biol
View full abstract on Pubmed
Accumulation of succinate controls activation of adipose tissue thermogenesis.
Authors: Authors: Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET.
Nature
View full abstract on Pubmed
Multiplexed Isobaric Tag-Based Profiling of Seven Murine Tissues Following In Vivo Nicotine Treatment Using a Minimalistic Proteomics Strategy.
Authors: Authors: Paulo JA, Jedrychowski MP, Chouchani ET, Kazak L, Gygi SP.
Proteomics
View full abstract on Pubmed
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Authors: Authors: Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA.
Nature
View full abstract on Pubmed
Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms.
Authors: Authors: Chouchani ET, Kazak L, Spiegelman BM.
J Biol Chem
View full abstract on Pubmed