Headshot of Ed Chouchani

Edward Chouchani, Ph.D.

Associate Professor of Cancer Biology (Dana-Farber Cancer Institute)
Associate Professor of Cell Biology (HMS)

Edward Chouchani, Ph.D., joined the faculty of Harvard Medical School as an Assistant Professor of Cell Biology in 2017. He received his Ph.D. in Biological Sciences at the University of Cambridge and MRC Mitochondrial Biology Unit. He then performed postdoctoral research at the Dana-Farber Cancer Institute and Harvard Medical School.

Research in the Chouchani Lab focuses on deciphering molecular mechanisms that drive metabolic disease, and using this information to develop targeted therapeutic strategies.  Mitochondria are critical hubs for metabolic signaling, and their dysfunction is key in the pathology of metabolic disease.  The Chouchani Lab combines mass spectrometry and targeted pharmacological approaches in vivo to understand how mitochondrial redox metabolism controls physiology in clinically informative mouse models of obesity and diabetes.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6212

360 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-632-3281

Lab Fax: 617-632-5363

Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.
Authors: Authors: Sun Y, Rahbani JF, Jedrychowski MP, Riley CL, Vidoni S, Bogoslavski D, Hu B, Dumesic PA, Zeng X, Wang AB, Knudsen NH, Kim CR, Marasciullo A, Millán JL, Chouchani ET, Kazak L, Spiegelman BM.
Nature
View full abstract on Pubmed
UCP1 governs liver extracellular succinate and inflammatory pathogenesis.
Authors: Authors: Mills EL, Harmon C, Jedrychowski MP, Xiao H, Garrity R, Tran NV, Bradshaw GA, Fu A, Szpyt J, Reddy A, Prendeville H, Danial NN, Gygi SP, Lynch L, Chouchani ET.
Nat Metab
View full abstract on Pubmed
Correction: Fragment-based covalent ligand discovery.
Authors: Authors: Lu W, Kostic M, Zhang T, Che J, Patricelli MP, Jones LH, Chouchani ET, Gray NS.
RSC Chem Biol
View full abstract on Pubmed
Fragment-based covalent ligand discovery.
Authors: Authors: Lu W, Kostic M, Zhang T, Che J, Patricelli MP, Jones LH, Chouchani ET, Gray NS.
RSC Chem Biol
View full abstract on Pubmed
AIDA and UCP1 snuggle up to prevent hypothermia.
Authors: Authors: Mills EL, Xiao H, Chouchani ET.
Nat Cell Biol
View full abstract on Pubmed
IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis.
Authors: Authors: Yan S, Kumari M, Xiao H, Jacobs C, Kochumon S, Jedrychowski M, Chouchani E, Ahmad R, Rosen ED.
J Clin Invest
View full abstract on Pubmed
Lactate fluxes mediated by the monocarboxylate transporter-1 are key determinants of the metabolic activity of beige adipocytes.
Authors: Authors: Lagarde D, Jeanson Y, Barreau C, Moro C, Peyriga L, Cahoreau E, Guissard C, Arnaud E, Galinier A, Bouzier-Sore AK, Pellerin L, Chouchani ET, Pénicaud L, Ader I, Portais JC, Casteilla L, Carrière A.
J Biol Chem
View full abstract on Pubmed
Lactate fluxes mediated by the monocarboxylate transporter-1 are key determinants of the metabolic activity of beige adipocytes.
Authors: Authors: Lagarde D, Jeanson Y, Barreau C, Moro C, Peyriga L, Cahoreau E, Guissard C, Arnaud E, Galinier A, Bouzier-Sore AK, Pellerin L, Chouchani ET, Penicaud L, Ader I, Portais JC, Casteilla L, Carriere A.
J Biol Chem
View full abstract on Pubmed
pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise.
Authors: Authors: Reddy A, Bozi LHM, Yaghi OK, Mills EL, Xiao H, Nicholson HE, Paschini M, Paulo JA, Garrity R, Laznik-Bogoslavski D, Ferreira JCB, Carl CS, Sjøberg KA, Wojtaszewski JFP, Jeppesen JF, Kiens B, Gygi SP, Richter EA, Mathis D, Chouchani ET.
Cell
View full abstract on Pubmed
Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction.
Authors: Authors: Madala HR, Helenius IT, Zhou W, Mills E, Zhang Y, Liu Y, Metelo AM, Kelley ML, Punganuru S, Kim KB, Olenchock B, Rhee E, Intlekofer AM, Iliopoulos O, Chouchani E, Yeh JJ.
Cancer Res
View full abstract on Pubmed