Headshot of Ed Chouchani

Edward Chouchani, Ph.D.

Associate Professor of Cancer Biology (Dana-Farber Cancer Institute)
Associate Professor of Cell Biology (HMS)

Edward Chouchani, Ph.D., joined the faculty of Harvard Medical School as an Assistant Professor of Cell Biology in 2017. He received his Ph.D. in Biological Sciences at the University of Cambridge and MRC Mitochondrial Biology Unit. He then performed postdoctoral research at the Dana-Farber Cancer Institute and Harvard Medical School.

Research in the Chouchani Lab focuses on deciphering molecular mechanisms that drive metabolic disease, and using this information to develop targeted therapeutic strategies.  Mitochondria are critical hubs for metabolic signaling, and their dysfunction is key in the pathology of metabolic disease.  The Chouchani Lab combines mass spectrometry and targeted pharmacological approaches in vivo to understand how mitochondrial redox metabolism controls physiology in clinically informative mouse models of obesity and diabetes.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6212

360 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-632-3281

Lab Fax: 617-632-5363

Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity.
Authors: Authors: Jedrychowski MP, Lu GZ, Szpyt J, Mariotti M, Garrity R, Paulo JA, Schweppe DK, Laznik-Bogoslavski D, Kazak L, Murphy MP, Gladyshev VN, Gygi SP, Chouchani ET, Spiegelman BM.
Proc Natl Acad Sci U S A
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Sample multiplexing for targeted pathway proteomics in aging mice.
Authors: Authors: Yu Q, Xiao H, Jedrychowski MP, Schweppe DK, Navarrete-Perea J, Knott J, Rogers J, Chouchani ET, Gygi SP.
Proc Natl Acad Sci U S A
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A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging.
Authors: Authors: Xiao H, Jedrychowski MP, Schweppe DK, Huttlin EL, Yu Q, Heppner DE, Li J, Long J, Mills EL, Szpyt J, He Z, Du G, Garrity R, Reddy A, Vaites LP, Paulo JA, Zhang T, Gray NS, Gygi SP, Chouchani ET.
Cell
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Author Correction: Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.
Authors: Authors: Langston PK, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei J, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Snyder NW, Horng T.
Nat Immunol
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Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.
Authors: Authors: Langston PK, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei J, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Snyder NW, Horng T.
Nat Immunol
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H+ transport is an integral function of the mitochondrial ADP/ATP carrier.
Authors: Authors: Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace DC, Spiegelman BM, Kirichok Y.
Nature
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Metabolic adaptation and maladaptation in adipose tissue.
Authors: Authors: Chouchani ET, Kajimura S.
Nat Metab
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New Advances in Adaptive Thermogenesis: UCP1 and Beyond.
Authors: Authors: Chouchani ET, Kazak L, Spiegelman BM.
Cell Metab
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Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity.
Authors: Authors: Kazak L, Rahbani JF, Samborska B, Lu GZ, Jedrychowski MP, Lajoie M, Zhang S, Ramsay LC, Dou FY, Tenen D, Chouchani ET, Dzeja P, Watson IR, Tsai L, Rosen ED, Spiegelman BM.
Nat Metab
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Coupling Krebs cycle metabolites to signalling in immunity and cancer.
Authors: Authors: Ryan DG, Murphy MP, Frezza C, Prag HA, Chouchani ET, O'Neill LA, Mills EL.
Nat Metab
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