Daniel Finley, Ph.D.

Daniel Finley, Ph.D.

Professor of Cell Biology (HMS)
C-404B
617-432-3492
Finley Lab

Dan Finley, Ph.D., received his undergraduate degree from Harvard University in biochemistry, and his graduate degree from MIT, with a focus on molecular biology. He stayed at MIT for his postdoctoral training before joining the Department of Cell Biology at HMS in 1988. He also currently sits on the Scientific Advisory Boards of Proteostasis and X-Chem Pharmaceuticals, and is a consultant for Genentech.

The Finley lab is interested in the ubiquitin-proteasome pathway and related regulatory systems. Specific topics include the mechanism of the proteasome, ubiquitin-like proteins, antizyme, and nonproteolytic functions of ubiquitination.

Harvard Medical School

Dept of Cell Biology, C-404B

240 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-432-3492

Reconfiguration of the proteasome during chaperone-mediated assembly.
Authors: Authors: Park S, Li X, Kim HM, Singh CR, Tian G, Hoyt MA, Lovell S, Battaile KP, Zolkiewski M, Coffino P, Roelofs J, Cheng Y, Finley D.
Nature
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Conformational dynamics of the Rpt6 ATPase in proteasome assembly and Rpn14 binding.
Authors: Authors: Ehlinger A, Park S, Fahmy A, Lary JW, Cole JL, Finley D, Walters KJ.
Structure
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A High-Throughput Screening Method for Identification of Inhibitors of the Deubiquitinating Enzyme USP14.
Authors: Authors: Lee BH, Finley D, King RW.
Curr Protoc Chem Biol
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Spg5 protein regulates the proteasome in quiescence.
Authors: Authors: Hanna J, Waterman D, Boselli M, Finley D.
J Biol Chem
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The ubiquitin-proteasome system of Saccharomyces cerevisiae.
Authors: Authors: Finley D, Ulrich HD, Sommer T, Kaiser P.
Genetics
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Cell biology. An ancient portal to proteolysis.
Authors: Authors: Matouschek A, Finley D.
Science
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A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication.
Authors: Authors: Nag DK, Finley D.
Virus Res
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Cell biology: Destruction deconstructed.
Authors: Authors: Tian G, Finley D.
Nature
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APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1.
Authors: Authors: Dimova NV, Hathaway NA, Lee BH, Kirkpatrick DS, Berkowitz ML, Gygi SP, Finley D, King RW.
Nat Cell Biol
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Binding of ubiquitin conjugates to proteasomes as visualized with native gels.
Authors: Authors: Elsasser S, Shi Y, Finley D.
Methods Mol Biol
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