Daniel Finley, Ph.D.

Daniel Finley, Ph.D.

Professor of Cell Biology (HMS)
C-404B
617-432-3492
Finley Lab

Dan Finley, Ph.D., received his undergraduate degree from Harvard University in biochemistry, and his graduate degree from MIT, with a focus on molecular biology. He stayed at MIT for his postdoctoral training before joining the Department of Cell Biology at HMS in 1988. He also currently sits on the Scientific Advisory Boards of Proteostasis and X-Chem Pharmaceuticals, and is a consultant for Genentech.

The Finley lab is interested in the ubiquitin-proteasome pathway and related regulatory systems. Specific topics include the mechanism of the proteasome, ubiquitin-like proteins, antizyme, and nonproteolytic functions of ubiquitination.

Harvard Medical School

Dept of Cell Biology, C-404B

240 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-432-3492

Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism.
Authors: Authors: Dange T, Smith D, Noy T, Rommel PC, Jurzitza L, Cordero RJ, Legendre A, Finley D, Goldberg AL, Schmidt M.
J Biol Chem
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Ubiquitin homeostasis is critical for synaptic development and function.
Authors: Authors: Chen PC, Bhattacharyya BJ, Hanna J, Minkel H, Wilson JA, Finley D, Miller RJ, Wilson SM.
J Neurosci
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An asymmetric interface between the regulatory and core particles of the proteasome.
Authors: Authors: Tian G, Park S, Lee MJ, Huck B, McAllister F, Hill CP, Gygi SP, Finley D.
Nat Struct Mol Biol
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Structural defects in the regulatory particle-core particle interface of the proteasome induce a novel proteasome stress response.
Authors: Authors: Park S, Kim W, Tian G, Gygi SP, Finley D.
J Biol Chem
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Misfolded proteins driven to destruction by Hul5.
Authors: Authors: Finley D.
Nat Cell Biol
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Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes.
Authors: Authors: Lee MJ, Lee BH, Hanna J, King RW, Finley D.
Mol Cell Proteomics
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Enhancement of proteasome activity by a small-molecule inhibitor of USP14.
Authors: Authors: Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, Chen PC, Gartner C, Dimova N, Hanna J, Gygi SP, Wilson SM, King RW, Finley D.
Nature
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Monoubiquitination of RPN10 regulates substrate recruitment to the proteasome.
Authors: Authors: Isasa M, Katz EJ, Kim W, Yugo V, González S, Kirkpatrick DS, Thomson TM, Finley D, Gygi SP, Crosas B.
Mol Cell
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Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2.
Authors: Authors: Chen X, Lee BH, Finley D, Walters KJ.
Mol Cell
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Assembly manual for the proteasome regulatory particle: the first draft.
Authors: Authors: Park S, Tian G, Roelofs J, Finley D.
Biochem Soc Trans
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