Daniel Finley, Ph.D.

Daniel Finley, Ph.D.

Professor of Cell Biology (HMS)
C-404B
617-432-3492
Finley Lab

Dan Finley, Ph.D., received his undergraduate degree from Harvard University in biochemistry, and his graduate degree from MIT, with a focus on molecular biology. He stayed at MIT for his postdoctoral training before joining the Department of Cell Biology at HMS in 1988. He also currently sits on the Scientific Advisory Boards of Proteostasis and X-Chem Pharmaceuticals, and is a consultant for Genentech.

The Finley lab is interested in the ubiquitin-proteasome pathway and related regulatory systems. Specific topics include the mechanism of the proteasome, ubiquitin-like proteins, antizyme, and nonproteolytic functions of ubiquitination.

Harvard Medical School

Dept of Cell Biology, C-404B

240 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-432-3492

Substrate degradation by the proteasome: a single-molecule kinetic analysis.
Authors: Authors: Lu Y, Lee BH, King RW, Finley D, Kirschner MW.
Science
View full abstract on Pubmed
K63 polyubiquitination is a new modulator of the oxidative stress response.
Authors: Authors: Silva GM, Finley D, Vogel C.
Nat Struct Mol Biol
View full abstract on Pubmed
Sculpting the proteome with small molecules.
Authors: Authors: King RW, Finley D.
Nat Chem Biol
View full abstract on Pubmed
Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression.
Authors: Authors: Liu Z, Chen P, Gao H, Gu Y, Yang J, Peng H, Xu X, Wang H, Yang M, Liu X, Fan L, Chen S, Zhou J, Sun Y, Ruan K, Cheng S, Komatsu M, White E, Li L, Ji H, Finley D, Hu R.
Cancer Cell
View full abstract on Pubmed
Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators.
Authors: Authors: Liu YP, Tsai IC, Morleo M, Oh EC, Leitch CC, Massa F, Lee BH, Parker DS, Finley D, Zaghloul NA, Franco B, Katsanis N.
J Clin Invest
View full abstract on Pubmed
Proteasomes associated with the Blm10 activator protein antagonize mitochondrial fission through degradation of the fission protein Dnm1.
Authors: Authors: Tar K, Dange T, Yang C, Yao Y, Bulteau AL, Salcedo EF, Braigen S, Bouillaud F, Finley D, Schmidt M.
J Biol Chem
View full abstract on Pubmed
Cuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity.
Authors: Authors: Hanna J, Waterman D, Isasa M, Elsasser S, Shi Y, Gygi S, Finley D.
J Biol Chem
View full abstract on Pubmed
WITHDRAWN: Blm10-proteasomes antagonize mitochondrial fission through degradation of Dnm1.
Authors: Authors: Tar K, Dange T, Yang C, Yao Y, Bulteau AL, Fernandez Salcedo E, Braigen S, Bouillaud F, Finley D, Schmidt M.
J Biol Chem
View full abstract on Pubmed
Regulation of proteasome activity in health and disease.
Authors: Authors: Schmidt M, Finley D.
Biochim Biophys Acta
View full abstract on Pubmed
Malfolded protein structure and proteostasis in lung diseases.
Authors: Authors: Balch WE, Sznajder JI, Budinger S, Finley D, Laposky AD, Cuervo AM, Benjamin IJ, Barreiro E, Morimoto RI, Postow L, Weissman AM, Gail D, Banks-Schlegel S, Croxton T, Gan W.
Am J Respir Crit Care Med
View full abstract on Pubmed