Daniel Finley, Ph.D.

Daniel Finley, Ph.D.

Professor of Cell Biology (HMS)
C-404B
617-432-3492
Finley Lab

Dan Finley, Ph.D., received his undergraduate degree from Harvard University in biochemistry, and his graduate degree from MIT, with a focus on molecular biology. He stayed at MIT for his postdoctoral training before joining the Department of Cell Biology at HMS in 1988. He also currently sits on the Scientific Advisory Boards of Proteostasis and X-Chem Pharmaceuticals, and is a consultant for Genentech.

The Finley lab is interested in the ubiquitin-proteasome pathway and related regulatory systems. Specific topics include the mechanism of the proteasome, ubiquitin-like proteins, antizyme, and nonproteolytic functions of ubiquitination.

Harvard Medical School

Dept of Cell Biology, C-404B

240 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-432-3492

Nucleotide-dependent switch in proteasome assembly mediated by the Nas6 chaperone.
Authors: Authors: Li F, Tian G, Langager D, Sokolova V, Finley D, Park S.
Proc Natl Acad Sci U S A
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Structural basis for dynamic regulation of the human 26S proteasome.
Authors: Authors: Chen S, Wu J, Lu Y, Ma YB, Lee BH, Yu Z, Ouyang Q, Finley DJ, Kirschner MW, Mao Y.
Proc Natl Acad Sci U S A
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Highly Multiplexed Quantitative Mass Spectrometry Analysis of Ubiquitylomes.
Authors: Authors: Rose CM, Isasa M, Ordureau A, Prado MA, Beausoleil SA, Jedrychowski MP, Finley DJ, Harper JW, Gygi SP.
Cell Syst
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USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites.
Authors: Authors: Lee BH, Lu Y, Prado MA, Shi Y, Tian G, Sun S, Elsasser S, Gygi SP, King RW, Finley D.
Nature
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Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation.
Authors: Authors: Choi WH, de Poot SA, Lee JH, Kim JH, Han DH, Kim YK, Finley D, Lee MJ.
Nat Commun
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Structure of an endogenous yeast 26S proteasome reveals two major conformational states.
Authors: Authors: Luan B, Huang X, Wu J, Mei Z, Wang Y, Xue X, Yan C, Wang J, Finley DJ, Shi Y, Wang F.
Proc Natl Acad Sci U S A
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Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome.
Authors: Authors: Shi Y, Chen X, Elsasser S, Stocks BB, Tian G, Lee BH, Shi Y, Zhang N, de Poot SA, Tuebing F, Sun S, Vannoy J, Tarasov SG, Engen JR, Finley D, Walters KJ.
Science
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Gates, Channels, and Switches: Elements of the Proteasome Machine.
Authors: Authors: Finley D, Chen X, Walters KJ.
Trends Biochem Sci
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Multiplexed, Proteome-Wide Protein Expression Profiling: Yeast Deubiquitylating Enzyme Knockout Strains.
Authors: Authors: Isasa M, Rose CM, Elsasser S, Navarrete-Perea J, Paulo JA, Finley DJ, Gygi SP.
J Proteome Res
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Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system.
Authors: Authors: Xu D, Shan B, Lee BH, Zhu K, Zhang T, Sun H, Liu M, Shi L, Liang W, Qian L, Xiao J, Wang L, Pan L, Finley D, Yuan J.
Elife
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