Daniel Finley, Ph.D.

Daniel Finley, Ph.D.

Professor of Cell Biology (HMS)
C-404B
617-432-3492
Finley Lab

Dan Finley, Ph.D., received his undergraduate degree from Harvard University in biochemistry, and his graduate degree from MIT, with a focus on molecular biology. He stayed at MIT for his postdoctoral training before joining the Department of Cell Biology at HMS in 1988. He also currently sits on the Scientific Advisory Boards of Proteostasis and X-Chem Pharmaceuticals, and is a consultant for Genentech.

The Finley lab is interested in the ubiquitin-proteasome pathway and related regulatory systems. Specific topics include the mechanism of the proteasome, ubiquitin-like proteins, antizyme, and nonproteolytic functions of ubiquitination.

Harvard Medical School

Dept of Cell Biology, C-404B

240 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-432-3492

The base of the proteasome regulatory particle exhibits chaperone-like activity.
Authors: Authors: Braun BC, Glickman M, Kraft R, Dahlmann B, Kloetzel PM, Finley D, Schmidt M.
Nat Cell Biol
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Functional analysis of the proteasome regulatory particle.
Authors: Authors: Glickman MH, Rubin DM, Fu H, Larsen CN, Coux O, Wefes I, Pfeifer G, Cjeka Z, Vierstra R, Baumeister W, Fried V, Finley D.
Mol Biol Rep
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Structure and functional analysis of the 26S proteasome subunits from plants.
Authors: Authors: Fu H, Girod PA, Doelling JH, van Nocker S, Hochstrasser M, Finley D, Vierstra RD.
Mol Biol Rep
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A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.
Authors: Authors: Glickman MH, Rubin DM, Coux O, Wefes I, Pfeifer G, Cjeka Z, Baumeister W, Fried VA, Finley D.
Cell
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Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome.
Authors: Authors: Rubin DM, Glickman MH, Larsen CN, Dhruvakumar S, Finley D.
EMBO J
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The regulatory particle of the Saccharomyces cerevisiae proteasome.
Authors: Authors: Glickman MH, Rubin DM, Fried VA, Finley D.
Mol Cell Biol
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NF-kappa B p105 processing via the ubiquitin-proteasome pathway.
Authors: Authors: Sears C, Olesen J, Rubin D, Finley D, Maniatis T.
J Biol Chem
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Protein translocation channels in the proteasome and other proteases.
Authors: Authors: Larsen CN, Finley D.
Cell
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ATPase and ubiquitin-binding proteins of the yeast proteasome.
Authors: Authors: Rubin DM, van Nocker S, Glickman M, Coux O, Wefes I, Sadis S, Fu H, Goldberg A, Vierstra R, Finley D.
Mol Biol Rep
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The molecular chaperone Ydj1 is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation.
Authors: Authors: Yaglom JA, Goldberg AL, Finley D, Sherman MY.
Mol Cell Biol
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