Daniel Finley, Ph.D.

Daniel Finley, Ph.D.

Professor of Cell Biology (HMS)
C-404B
617-432-3492
Finley Lab

Dan Finley, Ph.D., received his undergraduate degree from Harvard University in biochemistry, and his graduate degree from MIT, with a focus on molecular biology. He stayed at MIT for his postdoctoral training before joining the Department of Cell Biology at HMS in 1988. He also currently sits on the Scientific Advisory Boards of Proteostasis and X-Chem Pharmaceuticals, and is a consultant for Genentech.

The Finley lab is interested in the ubiquitin-proteasome pathway and related regulatory systems. Specific topics include the mechanism of the proteasome, ubiquitin-like proteins, antizyme, and nonproteolytic functions of ubiquitination.

Harvard Medical School

Dept of Cell Biology, C-404B

240 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-432-3492

Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26S proteasome.
Authors: Authors: Rubin DM, Coux O, Wefes I, Hengartner C, Young RA, Goldberg AL, Finley D.
Nature
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Characterization of a cDNA clone encoding E2-20K, a murine ubiquitin-conjugating enzyme.
Authors: Authors: Wefes I, Kaiser P, Schneider R, Pickart CM, Finley D.
Gene
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Proteolysis. The proteasome: a protein-degrading organelle?
Authors: Authors: Rubin DM, Finley D.
Curr Biol
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Synthetic signals for ubiquitin-dependent proteolysis.
Authors: Authors: Sadis S, Atienza C, Finley D.
Mol Cell Biol
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Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation.
Authors: Authors: Wefes I, Mastrandrea LD, Haldeman M, Koury ST, Tamburlin J, Pickart CM, Finley D.
Proc Natl Acad Sci U S A
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A ubiquitin mutant with specific defects in DNA repair and multiubiquitination.
Authors: Authors: Spence J, Sadis S, Haas AL, Finley D.
Mol Cell Biol
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p34Cdc28-mediated control of Cln3 cyclin degradation.
Authors: Authors: Yaglom J, Linskens MH, Sadis S, Rubin DM, Futcher B, Finley D.
Mol Cell Biol
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Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant.
Authors: Authors: Finley D, Sadis S, Monia BP, Boucher P, Ecker DJ, Crooke ST, Chau V.
Mol Cell Biol
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MHC-linked LMP gene products specifically alter peptidase activities of the proteasome.
Authors: Authors: Driscoll J, Brown MG, Finley D, Monaco JJ.
Nature
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A controlled breakdown: antigen processing and the turnover of viral proteins.
Authors: Authors: Driscoll J, Finley D.
Cell
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