Daniel Finley, Ph.D.

Daniel Finley, Ph.D.

Professor of Cell Biology (HMS)
C-404B
617-432-3492
Finley Lab

Dan Finley, Ph.D., received his undergraduate degree from Harvard University in biochemistry, and his graduate degree from MIT, with a focus on molecular biology. He stayed at MIT for his postdoctoral training before joining the Department of Cell Biology at HMS in 1988. He also currently sits on the Scientific Advisory Boards of Proteostasis and X-Chem Pharmaceuticals, and is a consultant for Genentech.

The Finley lab is interested in the ubiquitin-proteasome pathway and related regulatory systems. Specific topics include the mechanism of the proteasome, ubiquitin-like proteins, antizyme, and nonproteolytic functions of ubiquitination.

Harvard Medical School

Dept of Cell Biology, C-404B

240 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-432-3492

Ubiquitin chained and crosslinked.
Authors: Authors: Finley D.
Nat Cell Biol
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Role of a ubiquitin-like modification in polarized morphogenesis.
Authors: Authors: Dittmar GA, Wilkinson CR, Jedrzejewski PT, Finley D.
Science
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Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.
Authors: Authors: Jarosch E, Taxis C, Volkwein C, Bordallo J, Finley D, Wolf DH, Sommer T.
Nat Cell Biol
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Signal transduction. An alternative to destruction.
Authors: Authors: Finley D.
Nature
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The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release.
Authors: Authors: Köhler A, Cascio P, Leggett DS, Woo KM, Goldberg AL, Finley D.
Mol Cell
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The substrate translocation channel of the proteasome.
Authors: Authors: Köhler A, Bajorek M, Groll M, Moroder L, Rubin DM, Huber R, Glickman MH, Finley D.
Biochimie
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A gated channel into the proteasome core particle.
Authors: Authors: Groll M, Bajorek M, Köhler A, Moroder L, Rubin DM, Huber R, Glickman MH, Finley D.
Nat Struct Biol
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Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain.
Authors: Authors: Spence J, Gali RR, Dittmar G, Sherman F, Karin M, Finley D.
Cell
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Structure and mechanism of ATP-dependent proteases.
Authors: Authors: Schmidt M, Lupas AN, Finley D.
Curr Opin Chem Biol
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Chaperone rings in protein folding and degradation.
Authors: Authors: Horwich AL, Weber-Ban EU, Finley D.
Proc Natl Acad Sci U S A
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