Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.
Authors: Authors: Chouchani ET, Kazak L, Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J, Pierce KA, Laznik-Bogoslavski D, Vetrivelan R, Clish CB, Robinson AJ, Gygi SP, Spiegelman BM.
Nature
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A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function.
Authors: Authors: Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Chédotal A, Kajimura S, Gygi SP, Spiegelman BM.
Cell Metab
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PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer.
Authors: Authors: Kir S, Komaba H, Garcia AP, Economopoulos KP, Liu W, Lanske B, Hodin RA, Spiegelman BM.
Cell Metab
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A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.
Authors: Authors: Kazak L, Chouchani ET, Jedrychowski MP, Erickson BK, Shinoda K, Cohen P, Vetrivelan R, Lu GZ, Laznik-Bogoslavski D, Hasenfuss SC, Kajimura S, Gygi SP, Spiegelman BM.
Cell
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Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry.
Authors: Authors: Jedrychowski MP, Wrann CD, Paulo JA, Gerber KK, Szpyt J, Robinson MM, Nair KS, Gygi SP, Spiegelman BM.
Cell Metab
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Brown and Beige Fat: Physiological Roles beyond Heat Generation.
Authors: Authors: Kajimura S, Spiegelman BM, Seale P.
Cell Metab
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The future of brown adipose tissues in the treatment of type 2 diabetes.
Authors: Authors: Schrauwen P, van Marken Lichtenbelt WD, Spiegelman BM.
Diabetologia
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Brown and Beige Fat: Molecular Parts of a Thermogenic Machine.
Authors: Authors: Cohen P, Spiegelman BM.
Diabetes
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miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling.
Authors: Authors: Liu X, Xiao J, Zhu H, Wei X, Platt C, Damilano F, Xiao C, Bezzerides V, Boström P, Che L, Zhang C, Spiegelman BM, Rosenzweig A.
Cell Metab
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Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age.
Authors: Authors: Irving BA, Lanza IR, Henderson GC, Rao RR, Spiegelman BM, Nair KS.
J Clin Endocrinol Metab
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