Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

An ERK/Cdk5 axis controls the diabetogenic actions of PPAR?.
Authors: Authors: Banks AS, McAllister FE, Camporez JP, Zushin PJ, Jurczak MJ, Laznik-Bogoslavski D, Shulman GI, Gygi SP, Spiegelman BM.
Nature
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Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: age, diet, and PPAR? effects.
Authors: Authors: Cipolletta D, Cohen P, Spiegelman BM, Benoist C, Mathis D.
Proc Natl Acad Sci U S A
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G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy.
Authors: Authors: White JP, Wrann CD, Rao RR, Nair SK, Jedrychowski MP, You JS, Martínez-Redondo V, Gygi SP, Ruas JL, Hornberger TA, Wu Z, Glass DJ, Piao X, Spiegelman BM.
Proc Natl Acad Sci U S A
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Thrap3 docks on phosphoserine 273 of PPAR? and controls diabetic gene programming.
Authors: Authors: Choi JH, Choi SS, Kim ES, Jedrychowski MP, Yang YR, Jang HJ, Suh PG, Banks AS, Gygi SP, Spiegelman BM.
Genes Dev
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Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.
Authors: Authors: Kir S, White JP, Kleiner S, Kazak L, Cohen P, Baracos VE, Spiegelman BM.
Nature
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Response to Comment on Wu and Spiegelman. Irisin ERKs the fat. Diabetes 2014;63:381-383.
Authors: Authors: Spiegelman BM, Wrann C.
Diabetes
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Adipsin is an adipokine that improves ß cell function in diabetes.
Authors: Authors: Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, Kelly ME, Chatterjee Bhowmick D, Murano I, Cohen P, Banks AS, Khandekar MJ, Dietrich A, Flier JS, Cinti S, Blüher M, Danial NN, Berggren PO, Spiegelman BM.
Cell
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IRF4 is a key thermogenic transcriptional partner of PGC-1a.
Authors: Authors: Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED.
Cell
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Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.
Authors: Authors: Rao RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I, Jedrychowski MP, Ruas JL, Wrann CD, Lo JC, Camera DM, Lachey J, Gygi S, Seehra J, Hawley JA, Spiegelman BM.
Cell
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A smooth muscle-like origin for beige adipocytes.
Authors: Authors: Long JZ, Svensson KJ, Tsai L, Zeng X, Roh HC, Kong X, Rao RR, Lou J, Lokurkar I, Baur W, Castellot JJ, Rosen ED, Spiegelman BM.
Cell Metab
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