Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Retraction Notice to: Activation of the PPAR/PGC-1a Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype.
Authors: Authors: Wenz T, Diaz F, Spiegelman BM, Moraes CT.
Cell Metab
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The Cancer Drug Dasatinib Increases PGC-1a in Adipose Tissue but Has Adverse Effects on Glucose Tolerance in Obese Mice.
Authors: Authors: Sylow L, Long JZ, Lokurkar IA, Zeng X, Richter EA, Spiegelman BM.
Endocrinology
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Cachexia and Brown Fat: A Burning Issue in Cancer.
Authors: Authors: Kir S, Spiegelman BM.
Trends Cancer
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Attenuated PGC-1a Isoforms following Endurance Exercise with Blood Flow Restriction.
Authors: Authors: Conceição MS, Chacon-Mikahil MP, Telles GD, Libardi CA, Júnior EM, Vechin FC, DE Andrade AL, Gáspari AF, Brum PC, Cavaglieri CR, Serag S, Spiegelman BM, Hawley JA, Camera DM.
Med Sci Sports Exerc
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CACHEXIA & BROWN FAT: A BURNING ISSUE IN CANCER.
Authors: Authors: Kir S, Spiegelman BM.
Trends Cancer
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Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.
Authors: Authors: Chouchani ET, Kazak L, Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J, Pierce KA, Laznik-Bogoslavski D, Vetrivelan R, Clish CB, Robinson AJ, Gygi SP, Spiegelman BM.
Nature
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Cell biology of fat storage.
Authors: Authors: Cohen P, Spiegelman BM.
Mol Biol Cell
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Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation.
Authors: Authors: Zeng X, Jedrychowski MP, Chen Y, Serag S, Lavery GG, Gygi SP, Spiegelman BM.
Genes Dev
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The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria.
Authors: Authors: Long JZ, Svensson KJ, Bateman LA, Lin H, Kamenecka T, Lokurkar IA, Lou J, Rao RR, Chang MR, Jedrychowski MP, Paulo JA, Gygi SP, Griffin PR, Nomura DK, Spiegelman BM.
Cell
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CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury.
Authors: Authors: Bezzerides VJ, Platt C, Lerchenmüller C, Paruchuri K, Oh NL, Xiao C, Cao Y, Mann N, Spiegelman BM, Rosenzweig A.
JCI Insight
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