Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos.
Authors: Authors: Distel RJ, Ro HS, Rosen BS, Groves DL, Spiegelman BM.
Cell
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Nucleotide sequence and hormonal regulation of mouse glycerophosphate dehydrogenase mRNA during adipocyte and muscle cell differentiation.
Authors: Authors: Dobson DE, Groves DL, Spiegelman BM.
J Biol Chem
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Adipsin, the adipocyte serine protease: gene structure and control of expression by tumor necrosis factor.
Authors: Authors: Min HY, Spiegelman BM.
Nucleic Acids Res
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Recombinant retroviruses that transduce individual polyoma tumor antigens: effects on growth and differentiation.
Authors: Authors: Cherington V, Morgan B, Spiegelman BM, Roberts TM.
Proc Natl Acad Sci U S A
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Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes.
Authors: Authors: Hunt CR, Ro JH, Dobson DE, Min HY, Spiegelman BM.
Proc Natl Acad Sci U S A
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Heparin potentiation of 3T3-adipocyte stimulated angiogenesis: mechanisms of action on endothelial cells.
Authors: Authors: Castellot JJ, Kambe AM, Dobson DE, Spiegelman BM.
J Cell Physiol
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Regulation of gene expression during the differentiation of 3T3-adipocytes.
Authors: Authors: Spiegelman BM, Cook KS, Hunt CR.
Prog Clin Biol Res
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A developmentally regulated mRNA from 3T3 adipocytes encodes a novel serine protease homologue.
Authors: Authors: Cook KS, Groves DL, Min HY, Spiegelman BM.
Proc Natl Acad Sci U S A
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Developmentally regulated mRNAs in 3T3-adipocytes: analysis of transcriptional control.
Authors: Authors: Cook KS, Hunt CR, Spiegelman BM.
J Cell Biol
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Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes.
Authors: Authors: Spiegelman BM, Ginty CA.
Cell
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