Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development.
Authors: Authors: Spiegelman BM, Frank M, Green H.
J Biol Chem
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Differentiation-dependent stimulation of neovascularization and endothelial cell chemotaxis by 3T3 adipocytes.
Authors: Authors: Castellot JJ, Karnovsky MJ, Spiegelman BM.
Proc Natl Acad Sci U S A
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Decreases in tubulin and actin gene expression prior to morphological differentiation of 3T3 adipocytes.
Authors: Authors: Spiegelman BM, Farmer SR.
Cell
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Cyclic AMP-mediated control of lipogenic enzyme synthesis during adipose differentiation of 3T3 cells.
Authors: Authors: Spiegelman BM, Green H.
Cell
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Potent stimulation of vascular endothelial cell growth by differentiated 3T3 adipocytes.
Authors: Authors: Castellot JJ, Karnovsky MJ, Spiegelman BM.
Proc Natl Acad Sci U S A
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Control of specific protein biosynthesis during the adipose conversion of 3T3 cells.
Authors: Authors: Spiegelman BM, Green H.
J Biol Chem
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Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins.
Authors: Authors: Cleveland DW, Spiegelman BM, Kirschner MW.
J Biol Chem
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Multiple sites for the initiation of microtubule assembly in mammalian cells.
Authors: Authors: Spiegelman BM, Lopata MA, Kirschner MW.
Cell
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Aggregation of microtubule initiation sites preceding neurite outgrowth in mouse neuroblastoma cells.
Authors: Authors: Spiegelman BM, Lopata MA, Kirschner MW.
Cell
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Turnover of tubulin and the N site GTP in Chinese hamster ovary cells.
Authors: Authors: Spiegelman BM, Penningroth SM, Kirschner MW.
Cell
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