Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Adipsin and complement factor D activity: an immune-related defect in obesity.
Authors: Authors: Rosen BS, Cook KS, Yaglom J, Groves DL, Volanakis JE, Damm D, White T, Spiegelman BM.
Science
View full abstract on Pubmed
Adrenal glucocorticoids regulate adipsin gene expression in genetically obese mice.
Authors: Authors: Spiegelman BM, Lowell B, Napolitano A, Dubuc P, Barton D, Francke U, Groves DL, Cook KS, Flier JS.
J Biol Chem
View full abstract on Pubmed
Adipsin: regulation and dysregulation in obesity and other metabolic states.
Authors: Authors: Flier JS, Lowell B, Napolitano A, Usher P, Rosen B, Cook KS, Spiegelman B.
Recent Prog Horm Res
View full abstract on Pubmed
fos protooncogene and the regulation of gene expression in adipocyte differentiation.
Authors: Authors: Spiegelman BM, Distel RJ, Ro HS, Rosen BS, Satterberg B.
J Cell Biol
View full abstract on Pubmed
Regulation of gene expression in the adipocyte: implications for obesity and proto-oncogene function.
Authors: Authors: Spiegelman BM.
Trends Genet
View full abstract on Pubmed
Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation.
Authors: Authors: Cherington V, Brown M, Paucha E, St Louis J, Spiegelman BM, Roberts TM.
Mol Cell Biol
View full abstract on Pubmed
Common DNA binding site for Fos protein complexes and transcription factor AP-1.
Authors: Authors: Rauscher FJ, Sambucetti LC, Curran T, Distel RJ, Spiegelman BM.
Cell
View full abstract on Pubmed
Involvement of fos as a trans-acting factor in adipogenic gene expression.
Authors: Authors: Distel RJ, Spiegelman BM.
Prog Clin Biol Res
View full abstract on Pubmed
Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve.
Authors: Authors: Cook KS, Min HY, Johnson D, Chaplinsky RJ, Flier JS, Hunt CR, Spiegelman BM.
Science
View full abstract on Pubmed
Severely impaired adipsin expression in genetic and acquired obesity.
Authors: Authors: Flier JS, Cook KS, Usher P, Spiegelman BM.
Science
View full abstract on Pubmed