Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

DNA-binding activity of Jun is increased through its interaction with Fos.
Authors: Authors: Allegretto EA, Smeal T, Angel P, Spiegelman BM, Karin M.
J Cell Biochem
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Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine.
Authors: Authors: Lowell BB, Napolitano A, Usher P, Dulloo AG, Rosen BS, Spiegelman BM, Flier JS.
Endocrinology
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Control of the adipsin gene in adipocyte differentiation. Identification of distinct nuclear factors binding to single- and double-stranded DNA.
Authors: Authors: Wilkison WO, Min HY, Claffey KP, Satterberg BL, Spiegelman BM.
J Biol Chem
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Protooncogene c-fos as a transcription factor.
Authors: Authors: Distel RJ, Spiegelman BM.
Adv Cancer Res
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A direct role for C/EBP and the AP-I-binding site in gene expression linked to adipocyte differentiation.
Authors: Authors: Herrera R, Ro HS, Robinson GS, Xanthopoulos KG, Spiegelman BM.
Mol Cell Biol
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Insulin stimulates the acute release of adipsin from 3T3-L1 adipocytes.
Authors: Authors: Kitagawa K, Rosen BS, Spiegelman BM, Lienhard GE, Tanner LI.
Biochim Biophys Acta
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Obesity-linked regulation of the adipsin gene promoter in transgenic mice.
Authors: Authors: Platt KA, Min HY, Ross SR, Spiegelman BM.
Proc Natl Acad Sci U S A
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Targeting of nonexpressed genes in embryonic stem cells via homologous recombination.
Authors: Authors: Johnson RS, Sheng M, Greenberg ME, Kolodner RD, Papaioannou VE, Spiegelman BM.
Science
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Adipsin and complement factor D activity: an immune-related defect in obesity.
Authors: Authors: Rosen BS, Cook KS, Yaglom J, Groves DL, Volanakis JE, Damm D, White T, Spiegelman BM.
Science
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Adrenal glucocorticoids regulate adipsin gene expression in genetically obese mice.
Authors: Authors: Spiegelman BM, Lowell B, Napolitano A, Dubuc P, Barton D, Francke U, Groves DL, Cook KS, Flier JS.
J Biol Chem
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