Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Adipsin and an endogenous pathway of complement from adipose cells.
Authors: Authors: Choy LN, Rosen BS, Spiegelman BM.
J Biol Chem
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Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue.
Authors: Authors: White RT, Damm D, Hancock N, Rosen BS, Lowell BB, Usher P, Flier JS, Spiegelman BM.
J Biol Chem
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Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms.
Authors: Authors: Distel RJ, Robinson GS, Spiegelman BM.
J Biol Chem
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Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression.
Authors: Authors: Graves RA, Tontonoz P, Spiegelman BM.
Mol Cell Biol
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Biosynthetic regulation of monobutyrin, an adipocyte-secreted lipid with angiogenic activity.
Authors: Authors: Wilkison WO, Choy L, Spiegelman BM.
J Biol Chem
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Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor.
Authors: Authors: Graves RA, Tontonoz P, Ross SR, Spiegelman BM.
Genes Dev
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A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo.
Authors: Authors: Ross SR, Graves RA, Greenstein A, Platt KA, Shyu HL, Mellovitz B, Spiegelman BM.
Proc Natl Acad Sci U S A
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A direct role for c-fos in AP-1-dependent gene transcription.
Authors: Authors: Herrera R, Agarwal S, Walton K, Satterberg B, Distel RJ, Goodman R, Spiegelman BM, Roberts TM.
Cell Growth Differ
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Reduced adipsin mRNA and circulating adipsin protein are modulated by adrenal steroids in obese Zucker rats.
Authors: Authors: Johnson PR, Spiegelman B, Rosen B, Turkenkopf I, Ree H, Greenwood MR.
Am J Physiol
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1-Butyryl-glycerol: a novel angiogenesis factor secreted by differentiating adipocytes.
Authors: Authors: Dobson DE, Kambe A, Block E, Dion T, Lu H, Castellot JJ, Spiegelman BM.
Cell
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