Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes.
Authors: Authors: Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P.
J Biol Chem
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Biosynthesis of the vasoactive lipid monobutyrin. Central role of diacylglycerol.
Authors: Authors: Wilkison WO, Spiegelman BM.
J Biol Chem
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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.
Authors: Authors: Hotamisligil GS, Shargill NS, Spiegelman BM.
Science
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Pleiotropic effects of a null mutation in the c-fos proto-oncogene.
Authors: Authors: Johnson RS, Spiegelman BM, Papaioannou V.
Cell
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Growth and differentiation of embryonic stem cells that lack an intact c-fos gene.
Authors: Authors: Field SJ, Johnson RS, Mortensen RM, Papaioannou VE, Spiegelman BM, Greenberg ME.
Proc Natl Acad Sci U S A
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Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation.
Authors: Authors: Oliviero S, Robinson GS, Struhl K, Spiegelman BM.
Genes Dev
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Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene.
Authors: Authors: Ross SR, Choy L, Graves RA, Fox N, Solevjeva V, Klaus S, Ricquier D, Spiegelman BM.
Proc Natl Acad Sci U S A
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Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways.
Authors: Authors: Claffey KP, Wilkison WO, Spiegelman BM.
J Biol Chem
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Identification of a fat cell enhancer: analysis of requirements for adipose tissue-specific gene expression.
Authors: Authors: Graves RA, Tontonoz P, Platt KA, Ross SR, Spiegelman BM.
J Cell Biochem
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Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression.
Authors: Authors: Graves RA, Tontonoz P, Spiegelman BM.
Mol Cell Biol
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