Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes.
Authors: Authors: Hu E, Mueller E, Oliviero S, Papaioannou VE, Johnson R, Spiegelman BM.
EMBO J
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Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
Authors: Authors: Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM.
Proc Natl Acad Sci U S A
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mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
Authors: Authors: Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM.
Genes Dev
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Normal peripheral T-cell function in c-Fos-deficient mice.
Authors: Authors: Jain J, Nalefski EA, McCaffrey PG, Johnson RS, Spiegelman BM, Papaioannou V, Rao A.
Mol Cell Biol
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Characterization of the novel brown adipocyte cell line HIB 1B. Adrenergic pathways involved in regulation of uncoupling protein gene expression.
Authors: Authors: Klaus S, Choy L, Champigny O, Cassard-Doulcier AM, Ross S, Spiegelman B, Ricquier D.
J Cell Sci
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Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance.
Authors: Authors: Hofmann C, Lorenz K, Braithwaite SS, Colca JR, Palazuk BJ, Hotamisligil GS, Spiegelman BM.
Endocrinology
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Vasodilation of rat retinal microvessels induced by monobutyrin. Dysregulation in diabetes.
Authors: Authors: Halvorsen YD, Bursell SE, Wilkison WO, Clermont AC, Brittis M, McGovern TJ, Spiegelman BM.
J Clin Invest
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ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation.
Authors: Authors: Tontonoz P, Kim JB, Graves RA, Spiegelman BM.
Mol Cell Biol
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A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.
Authors: Authors: Johnson RS, van Lingen B, Papaioannou VE, Spiegelman BM.
Genes Dev
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Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity.
Authors: Authors: Ross SR, Graves RA, Spiegelman BM.
Genes Dev
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