Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Authors: Authors: Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM.
J Clin Invest
View full abstract on Pubmed
Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain.
Authors: Authors: Kim JB, Spotts GD, Halvorsen YD, Shih HM, Ellenberger T, Towle HC, Spiegelman BM.
Mol Cell Biol
View full abstract on Pubmed
Structural requirements for dimerization, glycosylation, secretion, and biological function of VPF/VEGF.
Authors: Authors: Claffey KP, Senger DR, Spiegelman BM.
Biochim Biophys Acta
View full abstract on Pubmed
PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene.
Authors: Authors: Tontonoz P, Hu E, Devine J, Beale EG, Spiegelman BM.
Mol Cell Biol
View full abstract on Pubmed
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.
Authors: Authors: Tontonoz P, Hu E, Spiegelman BM.
Cell
View full abstract on Pubmed
Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha.
Authors: Authors: Tontonoz P, Graves RA, Budavari AI, Erdjument-Bromage H, Lui M, Hu E, Tempst P, Spiegelman BM.
Nucleic Acids Res
View full abstract on Pubmed
Independent regulation of adipose tissue-specificity and obesity response of the adipsin promoter in transgenic mice.
Authors: Authors: Platt KA, Claffey KP, Wilkison WO, Spiegelman BM, Ross SR.
J Biol Chem
View full abstract on Pubmed
Tumor necrosis factor alpha: a key component of the obesity-diabetes link.
Authors: Authors: Hotamisligil GS, Spiegelman BM.
Diabetes
View full abstract on Pubmed
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
Authors: Authors: Hotamisligil GS, Budavari A, Murray D, Spiegelman BM.
J Clin Invest
View full abstract on Pubmed
Behavioral assessment of c-fos mutant mice.
Authors: Authors: Paylor R, Johnson RS, Papaioannou V, Spiegelman BM, Wehner JM.
Brain Res
View full abstract on Pubmed