Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Differential activation of adipogenesis by multiple PPAR isoforms.
Authors: Authors: Brun RP, Tontonoz P, Forman BM, Ellis R, Chen J, Evans RM, Spiegelman BM.
Genes Dev
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The circadian system of c-fos deficient mice.
Authors: Authors: Honrado GI, Johnson RS, Golombek DA, Spiegelman BM, Papaioannou VE, Ralph MR.
J Comp Physiol A
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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance.
Authors: Authors: Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM.
Science
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c-fos is not essential for v-abl-induced lymphomagenesis.
Authors: Authors: Saez E, Oppenheim H, Smoluk J, Andersen JW, Van Etten RA, Spiegelman BM.
Cancer Res
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Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.
Authors: Authors: Kopecky J, Clarke G, Enerbäck S, Spiegelman B, Kozak LP.
J Clin Invest
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15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.
Authors: Authors: Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM.
Cell
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Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha.
Authors: Authors: Hu E, Tontonoz P, Spiegelman BM.
Proc Natl Acad Sci U S A
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Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor gamma.
Authors: Authors: Tontonoz P, Hu E, Spiegelman BM.
Curr Opin Genet Dev
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c-fos is required for malignant progression of skin tumors.
Authors: Authors: Saez E, Rutberg SE, Mueller E, Oppenheim H, Smoluk J, Yuspa SH, Spiegelman BM.
Cell
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Transgenic mouse models of disease: altering adipose tissue function in vivo.
Authors: Authors: Ross SR, Graves RA, Choy L, Soleveva V, Spiegelman BM.
Ann N Y Acad Sci
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