Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Regulation of alternative pathway activation and C3a production by adipose cells.
Authors: Authors: Choy LN, Spiegelman BM.
Obes Res
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Cellular transformation and malignancy induced by ras require c-jun.
Authors: Authors: Johnson R, Spiegelman B, Hanahan D, Wisdom R.
Mol Cell Biol
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Differentiation of mouse keratinocytes is accompanied by PKC-dependent changes in AP-1 proteins.
Authors: Authors: Rutberg SE, Saez E, Glick A, Dlugosz AA, Spiegelman BM, Yuspa SH.
Oncogene
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Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy.
Authors: Authors: Watanabe Y, Johnson RS, Butler LS, Binder DK, Spiegelman BM, Papaioannou VE, McNamara JO.
J Neurosci
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Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.
Authors: Authors: Vidal-Puig A, Jimenez-Liñan M, Lowell BB, Hamann A, Hu E, Spiegelman B, Flier JS, Moller DE.
J Clin Invest
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Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase.
Authors: Authors: Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM.
J Biol Chem
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AdipoQ is a novel adipose-specific gene dysregulated in obesity.
Authors: Authors: Hu E, Liang P, Spiegelman BM.
J Biol Chem
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ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.
Authors: Authors: Kim JB, Spiegelman BM.
Genes Dev
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Differential activation of adipogenesis by multiple PPAR isoforms.
Authors: Authors: Brun RP, Tontonoz P, Forman BM, Ellis R, Chen J, Evans RM, Spiegelman BM.
Genes Dev
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The circadian system of c-fos deficient mice.
Authors: Authors: Honrado GI, Johnson RS, Golombek DA, Spiegelman BM, Papaioannou VE, Ralph MR.
J Comp Physiol A
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