Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.
Authors: Authors: Tontonoz P, Singer S, Forman BM, Sarraf P, Fletcher JA, Fletcher CD, Brun RP, Mueller E, Altiok S, Oppenheim H, Evans RM, Spiegelman BM.
Proc Natl Acad Sci U S A
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Identification of novel genes involved in adipose differentiation by differential display.
Authors: Authors: Hu E, Spiegelman BM.
Methods Mol Biol
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[TNF-alpha: molecular tie between obesity and insulin resistance].
Authors: Authors: Peraldi P, Spiegelman BM.
Journ Annu Diabetol Hotel Dieu
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Transgenic mice overexpressing the beta 1-adrenergic receptor in adipose tissue are resistant to obesity.
Authors: Authors: Soloveva V, Graves RA, Rasenick MM, Spiegelman BM, Ross SR.
Mol Endocrinol
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PPAR gamma and the control of adipogenesis.
Authors: Authors: Spiegelman BM, Hu E, Kim JB, Brun R.
Biochimie
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Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma.
Authors: Authors: Hu E, Kim JB, Sarraf P, Spiegelman BM.
Science
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Adipocyte differentiation: a transcriptional regulatory cascade.
Authors: Authors: Brun RP, Kim JB, Hu E, Altiok S, Spiegelman BM.
Curr Opin Cell Biol
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Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.
Authors: Authors: Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM.
Science
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Adipogenesis and obesity: rounding out the big picture.
Authors: Authors: Spiegelman BM, Flier JS.
Cell
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Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha.
Authors: Authors: Zhang B, Berger J, Hu E, Szalkowski D, White-Carrington S, Spiegelman BM, Moller DE.
Mol Endocrinol
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