Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

PPAR gamma and the molecular control of adipogenesis.
Authors: Authors: Brun RP, Spiegelman BM.
J Endocrinol
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Studies of the mechanism of inhibition of insulin signaling by tumor necrosis factor-alpha.
Authors: Authors: Peraldi P, Spiegelman BM.
J Endocrinol
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Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.
Authors: Authors: Peraldi P, Xu M, Spiegelman BM.
J Clin Invest
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Opposing activities of c-Fos and Fra-2 on AP-1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters.
Authors: Authors: Rutberg SE, Saez E, Lo S, Jang SI, Markova N, Spiegelman BM, Yuspa SH.
Oncogene
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Peroxisome proliferator-activated receptor gamma and the control of adipogenesis.
Authors: Authors: Brun RP, Kim JB, Hu E, Spiegelman BM.
Curr Opin Lipidol
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PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A.
Authors: Authors: Altiok S, Xu M, Spiegelman BM.
Genes Dev
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Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments.
Authors: Authors: Barlow C, Schroeder M, Lekstrom-Himes J, Kylefjord H, Deng CX, Wynshaw-Boris A, Spiegelman BM, Xanthopoulos KG.
Nucleic Acids Res
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Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene.
Authors: Authors: Ericsson J, Jackson SM, Kim JB, Spiegelman BM, Edwards PA.
J Biol Chem
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Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance.
Authors: Authors: Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BM.
Diabetes
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Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter.
Authors: Authors: Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, Sarraf P, Spiegelman BM, Lowell BB.
J Biol Chem
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