Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

TNF-alpha and insulin resistance: summary and future prospects.
Authors: Authors: Peraldi P, Spiegelman B.
Mol Cell Biochem
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c-Fos deficiency inhibits induction of mRNA for some, but not all, neurotransmitter biosynthetic enzymes by immobilization stress.
Authors: Authors: Serova LI, Saez E, Spiegelman BM, Sabban EL.
J Neurochem
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PPARgamma in monocytes: less pain, any gain?
Authors: Authors: Spiegelman BM.
Cell
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ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand.
Authors: Authors: Kim JB, Wright HM, Wright M, Spiegelman BM.
Proc Natl Acad Sci U S A
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PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
Authors: Authors: Spiegelman BM.
Diabetes
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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Authors: Authors: Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM.
Cell
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Terminal differentiation of human breast cancer through PPAR gamma.
Authors: Authors: Mueller E, Sarraf P, Tontonoz P, Evans RM, Martin KJ, Zhang M, Fletcher C, Singer S, Spiegelman BM.
Mol Cell
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Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.
Authors: Authors: Kim JB, Sarraf P, Wright M, Yao KM, Mueller E, Solanes G, Lowell BB, Spiegelman BM.
J Clin Invest
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Regulation of gene expression of catecholamine biosynthetic enzymes by stress.
Authors: Authors: Sabban EL, Nankova BB, Serova LI, Hiremagalur B, Rusnak M, Saez E, Spiegelman B, Kvetnanský R.
Adv Pharmacol
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Peroxisome proliferator-activated receptor gamma: A key regulator of adipogenesis and systemic insulin sensitivity.
Authors: Authors: Spiegelman BM.
Eur J Med Res
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