Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Loss-of-function mutations in PPAR gamma associated with human colon cancer.
Authors: Authors: Sarraf P, Mueller E, Smith WM, Wright HM, Kum JB, Aaltonen LA, de la Chapelle A, Spiegelman BM, Eng C.
Mol Cell
View full abstract on Pubmed
Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor gamma and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo.
Authors: Authors: Devine JH, Eubank DW, Clouthier DE, Tontonoz P, Spiegelman BM, Hammer RE, Beale EG.
J Biol Chem
View full abstract on Pubmed
ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose.
Authors: Authors: Foretz M, Pacot C, Dugail I, Lemarchand P, Guichard C, Le Lièpvre X, Berthelier-Lubrano C, Spiegelman B, Kim JB, Ferré P, Foufelle F.
Mol Cell Biol
View full abstract on Pubmed
Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma.
Authors: Authors: Demetri GD, Fletcher CD, Mueller E, Sarraf P, Naujoks R, Campbell N, Spiegelman BM, Singer S.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines.
Authors: Authors: King FJ, Hu E, Harris DF, Sarraf P, Spiegelman BM, Roberts TM.
Mol Cell Biol
View full abstract on Pubmed
Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity.
Authors: Authors: Wu Z, Rosen ED, Brun R, Hauser S, Adelmant G, Troy AE, McKeon C, Darlington GJ, Spiegelman BM.
Mol Cell
View full abstract on Pubmed
A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis.
Authors: Authors: Ho IC, Kim JH, Rooney JW, Spiegelman BM, Glimcher LH.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Posttranscriptional control of adipocyte differentiation through activation of phosphoinositide 3-kinase.
Authors: Authors: Sakaue H, Ogawa W, Matsumoto M, Kuroda S, Takata M, Sugimoto T, Spiegelman BM, Kasuga M.
J Biol Chem
View full abstract on Pubmed
Differentiation and reversal of malignant changes in colon cancer through PPARgamma.
Authors: Authors: Sarraf P, Mueller E, Jones D, King FJ, DeAngelo DJ, Partridge JB, Holden SA, Chen LB, Singer S, Fletcher C, Spiegelman BM.
Nat Med
View full abstract on Pubmed
Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1.
Authors: Authors: Tabor DE, Kim JB, Spiegelman BM, Edwards PA.
J Biol Chem
View full abstract on Pubmed