Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation.
Authors: Authors: Wright HM, Clish CB, Mikami T, Hauser S, Yanagi K, Hiramatsu R, Serhan CN, Spiegelman BM.
J Biol Chem
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Molecular regulation of adipogenesis.
Authors: Authors: Rosen ED, Spiegelman BM.
Annu Rev Cell Dev Biol
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Transcriptional activation of adipogenesis.
Authors: Authors: Wu Z, Puigserver P, Spiegelman BM.
Curr Opin Cell Biol
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Activation of PPARgamma coactivator-1 through transcription factor docking.
Authors: Authors: Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman BM.
Science
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PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro.
Authors: Authors: Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, Mortensen RM.
Mol Cell
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Chemical probes that differentially modulate peroxisome proliferator-activated receptor alpha and BLTR, nuclear and cell surface receptors for leukotriene B(4).
Authors: Authors: Devchand PR, Hihi AK, Perroud M, Schleuning WD, Spiegelman BM, Wahli W.
J Biol Chem
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Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism.
Authors: Authors: Fajas L, Schoonjans K, Gelman L, Kim JB, Najib J, Martin G, Fruchart JC, Briggs M, Spiegelman BM, Auwerx J.
Mol Cell Biol
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Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2.
Authors: Authors: Tabor DE, Kim JB, Spiegelman BM, Edwards PA.
J Biol Chem
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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.
Authors: Authors: Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM.
Cell
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An adipogenic cofactor bound by the differentiation domain of PPARgamma.
Authors: Authors: Castillo G, Brun RP, Rosenfield JK, Hauser S, Park CW, Troy AE, Wright ME, Spiegelman BM.
EMBO J
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