Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Regulation of adipogenesis and energy balance by PPARgamma and PGC-1.
Authors: Authors: Spiegelman BM, Puigserver P, Wu Z.
Int J Obes Relat Metab Disord
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Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer.
Authors: Authors: Mueller E, Smith M, Sarraf P, Kroll T, Aiyer A, Kaufman DS, Oh W, Demetri G, Figg WD, Zhou XP, Eng C, Spiegelman BM, Kantoff PW.
Proc Natl Acad Sci U S A
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Peroxisome proliferator-activated receptor gamma ligands and atherosclerosis: ending the heartache.
Authors: Authors: Rosen ED, Spiegelman BM.
J Clin Invest
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PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected].
Authors: Authors: Kroll TG, Sarraf P, Pecciarini L, Chen CJ, Mueller E, Spiegelman BM, Fletcher JA.
Science
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Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1.
Authors: Authors: Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, Spiegelman BM.
Mol Cell
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Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation.
Authors: Authors: Yoon JC, Chickering TW, Rosen ED, Dussault B, Qin Y, Soukas A, Friedman JM, Holmes WE, Spiegelman BM.
Mol Cell Biol
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Degradation of the peroxisome proliferator-activated receptor gamma is linked to ligand-dependent activation.
Authors: Authors: Hauser S, Adelmant G, Sarraf P, Wright HM, Mueller E, Spiegelman BM.
J Biol Chem
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Transcriptional regulation of adipogenesis.
Authors: Authors: Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM.
Genes Dev
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Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1.
Authors: Authors: Tcherepanova I, Puigserver P, Norris JD, Spiegelman BM, McDonnell DP.
J Biol Chem
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Towards a molecular understanding of adaptive thermogenesis.
Authors: Authors: Lowell BB, Spiegelman BM.
Nature
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