Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway.
Authors: Authors: Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, Spiegelman BM.
Genes Dev
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A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer.
Authors: Authors: Kulke MH, Demetri GD, Sharpless NE, Ryan DP, Shivdasani R, Clark JS, Spiegelman BM, Kim H, Mayer RJ, Fuchs CS.
Cancer J
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Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.
Authors: Authors: Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, Spiegelman BM.
Mol Cell
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PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth.
Authors: Authors: Rosen ED, Spiegelman BM.
J Biol Chem
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Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.
Authors: Authors: Tsukiyama-Kohara K, Poulin F, Kohara M, DeMaria CT, Cheng A, Wu Z, Gingras AC, Katsume A, Elchebly M, Spiegelman BM, Harper ME, Tremblay ML, Sonenberg N.
Nat Med
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CREB regulates hepatic gluconeogenesis through the coactivator PGC-1.
Authors: Authors: Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M.
Nature
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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
Authors: Authors: Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM.
Nature
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Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.
Authors: Authors: Michael LF, Wu Z, Cheatham RB, Puigserver P, Adelmant G, Lehman JJ, Kelly DP, Spiegelman BM.
Proc Natl Acad Sci U S A
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Obesity and the regulation of energy balance.
Authors: Authors: Spiegelman BM, Flier JS.
Cell
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The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.
Authors: Authors: Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW.
Nat Med
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