Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators.
Authors: Authors: Spiegelman BM.
Novartis Found Symp
View full abstract on Pubmed
The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle.
Authors: Authors: Arany Z, Lebrasseur N, Morris C, Smith E, Yang W, Ma Y, Chin S, Spiegelman BM.
Cell Metab
View full abstract on Pubmed
Adipocytes as regulators of energy balance and glucose homeostasis.
Authors: Authors: Rosen ED, Spiegelman BM.
Nature
View full abstract on Pubmed
"The adipocyte: a multifunctional cell".
Authors: Authors: Spiegelman BM, Enerbäck S.
Cell Metab
View full abstract on Pubmed
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.
Authors: Authors: Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman GI, Spiegelman BM, Lowell BB.
Cell Metab
View full abstract on Pubmed
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.
Authors: Authors: Handschin C, Spiegelman BM.
Endocr Rev
View full abstract on Pubmed
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.
Authors: Authors: Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzalez FJ, Grimaldi PA, Kadowaki T, Lazar MA, O'Rahilly S, Palmer CN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, Wahli W.
Pharmacol Rev
View full abstract on Pubmed
Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex.
Authors: Authors: Cooper MP, Qu L, Rohas LM, Lin J, Yang W, Erdjument-Bromage H, Tempst P, Spiegelman BM.
Genes Dev
View full abstract on Pubmed
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription.
Authors: Authors: Sandri M, Lin J, Handschin C, Yang W, Arany ZP, Lecker SH, Goldberg AL, Spiegelman BM.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.
Authors: Authors: St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM.
Cell
View full abstract on Pubmed