Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.
Authors: Authors: Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC.
Proc Natl Acad Sci U S A
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Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha.
Authors: Authors: Arany Z, Novikov M, Chin S, Ma Y, Rosenzweig A, Spiegelman BM.
Proc Natl Acad Sci U S A
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Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism.
Authors: Authors: Rhee J, Ge H, Yang W, Fan M, Handschin C, Cooper M, Lin J, Li C, Spiegelman BM.
J Biol Chem
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Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation.
Authors: Authors: Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM.
Cell Metab
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The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes.
Authors: Authors: Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B, Moore DD.
Cell Metab
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Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha.
Authors: Authors: Handschin C, Lin J, Rhee J, Peyer AK, Chin S, Wu PH, Meyer UA, Spiegelman BM.
Cell
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TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.
Authors: Authors: Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB.
Science
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Metabolic control through the PGC-1 family of transcription coactivators.
Authors: Authors: Lin J, Handschin C, Spiegelman BM.
Cell Metab
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Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.
Authors: Authors: Andersen G, Wegner L, Yanagisawa K, Rose CS, Lin J, Glümer C, Drivsholm T, Borch-Johnsen K, Jørgensen T, Hansen T, Spiegelman BM, Pedersen O.
J Med Genet
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Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.
Authors: Authors: Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, Spiegelman BM.
Cell Metab
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