Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase.
Authors: Authors: Lustig Y, Ruas JL, Estall JL, Lo JC, Devarakonda S, Laznik D, Choi JH, Ono H, Olsen JV, Spiegelman BM.
Genes Dev
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PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination.
Authors: Authors: Handschin C, Spiegelman BM.
Cell Metab
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The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1a/ATF6a complex.
Authors: Authors: Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM.
Cell Metab
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Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.
Authors: Authors: Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM.
J Clin Invest
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C/EBPß controls exercise-induced cardiac growth and protects against pathological cardiac remodeling.
Authors: Authors: Boström P, Mann N, Wu J, Quintero PA, Plovie ER, Panáková D, Gupta RK, Xiao C, MacRae CA, Rosenzweig A, Spiegelman BM.
Cell
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PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types.
Authors: Authors: Rasbach KA, Gupta RK, Ruas JL, Wu J, Naseri E, Estall JL, Spiegelman BM.
Proc Natl Acad Sci U S A
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Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons.
Authors: Authors: Chakkalakal JV, Nishimune H, Ruas JL, Spiegelman BM, Sanes JR.
Development
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Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.
Authors: Authors: Choi JH, Banks AS, Estall JL, Kajimura S, Boström P, Laznik D, Ruas JL, Chalmers MJ, Kamenecka TM, Blüher M, Griffin PR, Spiegelman BM.
Nature
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NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection.
Authors: Authors: Volakakis N, Kadkhodaei B, Joodmardi E, Wallis K, Panman L, Silvaggi J, Spiegelman BM, Perlmann T.
Proc Natl Acad Sci U S A
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Transcriptional control of brown fat development.
Authors: Authors: Kajimura S, Seale P, Spiegelman BM.
Cell Metab
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