Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Transcriptional control of preadipocyte determination by Zfp423.
Authors: Authors: Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM.
Nature
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For a pragmatic approach to exercise studies.
Authors: Authors: Handschin C, Summermatter S, LeBrasseur NK, Lin J, Spiegelman BM.
J Appl Physiol (1985)
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A rationale for SDS-PAGE of MHC isoforms as a gold standard for determining contractile phenotype.
Authors: Authors: Pandorf CE, Caiozzo VJ, Haddad F, Baldwin KM.
J Appl Physiol (1985)
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PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis.
Authors: Authors: Estall JL, Ruas JL, Choi CS, Laznik D, Badman M, Maratos-Flier E, Shulman GI, Spiegelman BM.
Proc Natl Acad Sci U S A
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Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging.
Authors: Authors: Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT.
Proc Natl Acad Sci U S A
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Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.
Authors: Authors: Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM.
Nature
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PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function.
Authors: Authors: Kleiner S, Nguyen-Tran V, Baré O, Huang X, Spiegelman B, Wu Z.
J Biol Chem
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Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.
Authors: Authors: Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM.
Diabetes
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Transcriptional control of brown adipocyte development and physiological function--of mice and men.
Authors: Authors: Seale P, Kajimura S, Spiegelman BM.
Genes Dev
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Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.
Authors: Authors: Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI.
Proc Natl Acad Sci U S A
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