Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells.
Authors: Authors: Gupta RK, Mepani RJ, Kleiner S, Lo JC, Khandekar MJ, Cohen P, Frontini A, Bhowmick DC, Ye L, Cinti S, Spiegelman BM.
Cell Metab
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FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis.
Authors: Authors: Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM.
Genes Dev
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A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.
Authors: Authors: Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM.
Nature
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A chemical screen probing the relationship between mitochondrial content and cell size.
Authors: Authors: Kitami T, Logan DJ, Negri J, Hasaka T, Tolliday NJ, Carpenter AE, Spiegelman BM, Mootha VK.
PLoS One
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Identifying novel transcriptional components controlling energy metabolism.
Authors: Authors: Gupta RK, Rosen ED, Spiegelman BM.
Cell Metab
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QnAs with Bruce M. Spiegelman.
Authors: Authors: Spiegelman BM.
Proc Natl Acad Sci U S A
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Molecular mechanisms of cancer development in obesity.
Authors: Authors: Khandekar MJ, Cohen P, Spiegelman BM.
Nat Rev Cancer
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Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1a/ERR? complex.
Authors: Authors: Devarakonda S, Gupta K, Chalmers MJ, Hunt JF, Griffin PR, Van Duyne GD, Spiegelman BM.
Proc Natl Acad Sci U S A
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Antidiabetic actions of a non-agonist PPAR? ligand blocking Cdk5-mediated phosphorylation.
Authors: Authors: Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Schürer SC, Vidovic D, Shulman GI, Spiegelman BM, Griffin PR.
Nature
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Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo.
Authors: Authors: Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, Flier JS, Kharitonenkov A, Spiegelman BM, Maratos-Flier E.
Endocrinology
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