Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

PGC1a expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.
Authors: Authors: Vazquez F, Lim JH, Chim H, Bhalla K, Girnun G, Pierce K, Clish CB, Granter SR, Widlund HR, Spiegelman BM, Puigserver P.
Cancer Cell
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Adaptive thermogenesis in adipocytes: is beige the new brown?
Authors: Authors: Wu J, Cohen P, Spiegelman BM.
Genes Dev
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A PGC-1a isoform induced by resistance training regulates skeletal muscle hypertrophy.
Authors: Authors: Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, Leinwand LA, Spiegelman BM.
Cell
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TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis.
Authors: Authors: Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM.
Cell
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Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.
Authors: Authors: Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM.
Cell
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A novel therapeutic approach to treating obesity through modulation of TGFß signaling.
Authors: Authors: Koncarevic A, Kajimura S, Cornwall-Brady M, Andreucci A, Pullen A, Sako D, Kumar R, Grinberg AV, Liharska K, Ucran JA, Howard E, Spiegelman BM, Seehra J, Lachey J.
Endocrinology
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Development of insulin resistance in mice lacking PGC-1a in adipose tissues.
Authors: Authors: Kleiner S, Mepani RJ, Laznik D, Ye L, Jurczak MJ, Jornayvaz FR, Estall JL, Chatterjee Bhowmick D, Shulman GI, Spiegelman BM.
Proc Natl Acad Sci U S A
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Se-Jin Lee, myostatin discoverer, elected to the National Academy of Science.
Authors: Authors: Glass DJ, Spiegelman BM.
Skelet Muscle
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Elevated PGC-1a activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS.
Authors: Authors: Da Cruz S, Parone PA, Lopes VS, Lillo C, McAlonis-Downes M, Lee SK, Vetto AP, Petrosyan S, Marsala M, Murphy AN, Williams DS, Spiegelman BM, Cleveland DW.
Cell Metab
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PPAR? agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein.
Authors: Authors: Ohno H, Shinoda K, Spiegelman BM, Kajimura S.
Cell Metab
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