Adrian Salic

Adrian Salic, Ph.D.

Professor of Cell Biology (HMS)
LHRRB 401A
617-432-6341
Salic Lab

Adrian Salic, Ph.D. was appointed Assistant Professor of Cell Biology in 2005, after completing his postdoctoral research in the Department of Systems Biology at Harvard Medical School. He received his PhD from Harvard University in 2000. His development of novel tools to detect DNA and RNA synthesis resulted in the creation of the commerically-available "Click-iT" EdU and EU kits that are now widely used by labs around the world.

The Salic lab studies biochemical and cellular mechanisms involved in signal transduction through the Hedgehog signaling pathway. We also develop and apply new chemical technologies to study the cell biology of lipids.

Harvard Medical School

Dept. of Cell Biology, LHRRB 401A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-6341

Lab fax: 617-432-1190

Evidence for an upper limit to mitotic spindle length.
Authors: Authors: Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ.
Curr Biol
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Detection of S-phase cell cycle progression using 5-ethynyl-2'-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2'-deoxyuridine antibodies.
Authors: Authors: Buck SB, Bradford J, Gee KR, Agnew BJ, Clarke ST, Salic A.
Biotechniques
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A chemical method for fast and sensitive detection of DNA synthesis in vivo.
Authors: Authors: Salic A, Mitchison TJ.
Proc Natl Acad Sci U S A
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Lrp6 is required for convergent extension during Xenopus gastrulation.
Authors: Authors: Tahinci E, Thorne CA, Franklin JL, Salic A, Christian KM, Lee LA, Coffey RJ, Lee E.
Development
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Bub1 is essential for assembly of the functional inner centromere.
Authors: Authors: Boyarchuk Y, Salic A, Dasso M, Arnaoutov A.
J Cell Biol
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Identifying small molecule inhibitors of the ubiquitin-proteasome pathway in Xenopus egg extracts.
Authors: Authors: Salic A, King RW.
Methods Enzymol
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Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis.
Authors: Authors: Salic A, Waters JC, Mitchison TJ.
Cell
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The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly.
Authors: Authors: Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H.
Cell
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The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway.
Authors: Authors: Lee E, Salic A, Krüger R, Heinrich R, Kirschner MW.
PLoS Biol
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Anteroposterior patterning in hemichordates and the origins of the chordate nervous system.
Authors: Authors: Lowe CJ, Wu M, Salic A, Evans L, Lander E, Stange-Thomann N, Gruber CE, Gerhart J, Kirschner M.
Cell
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