2024-2025
DATESPEAKERLABTALK TITLE
September 11, 2024Alex TruongHMS IT"Research computing at HMS: How we can make your (research) life better"
September 18, 2024Meiying NgChouchani"A druggable redox switch on SHP1 controls macrophage inflammation"
September 25, 2024Songhua HuHaigis“A novel role of sirtuin-generated byproduct in regulating fatty acid oxidation”
October 9, 2024Felix KrausHarper“Systematic Analysis of Cellular Proteomes and Lipidomes in Lysosomal Storage Disorders”
October 23, 2024Rishov GoswamiDanial"Contribution of lipid metabolism to the tumorigenic potential of the BRAF fusion oncoprotein in pediatric gliomas"
October 30, 2024Karl-Uwe (Kalle) ReusswigPellman"Exploring how chromosome stability is affected by the formation of an MN body around a chromosome that was exposed to the cytoplasm during the previous cell cycle"
November 6, 2024Steven ShukenGygi"Quantifying sites of modification and mutation with the GoDig targeted mass spectrometry platform"
November 13, 2024Manuel Osorio ValerianoFarnung"Looping the genome: cryo-EM analysis of CTCF-nucleosome complexes"
November 20, 2024Jim Gould, Ph.D.HMS/HSDM Office for Postdoctoral Fellows"Making the Most of Your Postdoc"
December 11, 2024Jingyi ChiLiberles"Peering into the cellular and functional diversity of the sympathetic nervous system"
January 10, 2025Hyeongju KimLee"Identifying mechanism of translation regulation by alphavirus"
January 17, 2025Yingqian ChenKing"Evaluating the role of inhibitory phosphorylation of E2 enzyme UBE2H"
January 24, 2025Konstantinos NakosSubramanian“How does a mitotic kinase localize at the spindle midzone?”
February 7, 2025Bryan SeguinotFinley"Landscaping the RBC Proteome"
February 14, 2024Anne Van Der LeunBernstein"The cause and consequence of DNA hypomethylation in T cells"
February 21, 2025Pedro Latorre-MuroPuigserver"Mechanisms of mitochondrial adaptive respiration"
February 28, 2025Haruka ChinoShao"Requirements for degrading a misoriented protein at the ER"
March 14, 2025Juntao YuMoazed"Molecular Basis of Chromatin-Based Epigenetic Memory"
March 21, 2025Diana HoVan Vactor"Motor neuron subtype specificity of TDP-43 responses in Drosophila"
March 28, 2025Gustavo Scanavachi Moreira CamposKirchhausen“Real time visualization of Notch synapse and Notch signaling"
April 11, 2025Jared JohnsonCantley"An Atlas of Substrate Specificities for the Human Protein Kinome"
April 18, 2025Xiangkun HanBrugge"NRF2 Regulates Tumor Immunity Beyond Oxidative Stress Responses"
April 25, 2025Ariana Vargas Castillo Spiegelman"Heterogeneity of beige adipocytes: Evidences of different thermogenic subclasses"
May 2, 2025Krystle KalafutManning"A hierarchy of signals dictates hepatic mTORC1 activation by feeding and influences hepatic insulin signaling"
May 9, 2025Kean Hean OoiGygi"PoolPARTEA for Electrophile Fragments in the multidimensional universe"
May 16, 2025Chan LeeHarper"DMXL1 supports a lysosomal homeostatic response induced by TRPML1 activation"
May 30, 2025Chris NardoneRapoport“Towards elucidating how eukaryotic cells regulate organelle pH”
June 13, 2025David VanderwallGygi"KinoPlex: A Structural Atlas of the Human Kinome"

2023-2024
DATESPEAKERLABTALK TITLE
Sep 6, 2023Amir KargerResearch ComputingResearch Computing at HMS: We will make your (research) life better
Sep 20, 2023Brandon GassawayGygiInvestigating T Cell Activation Using the Phosphorylation Integrated Thermal Shift Assay
Sep 27, 2023Rudolf PisaRapoportThrough Thick and Thin: How a Thin Membrane Drives Substrate Selection During ER-Associated Degradation
Oct 4, 2023Kiran KurmiHaigisRegulation of mitochondrial mass during T cell activation
Oct 25, 2023Nils BurgerChouchaniAn Atlas of the Zinc binding Proteome identifies Glutathione Reductase as Zinc-targetable cancer vulnerability
Nov 1, 2023Philip DumesicSpiegelmanRBM43 controls PGC1α translation, a PGC1α-STING signaling axis, and glucose homeostasis
Nov 8, 2023Arda MizrakHarperSingle molecule tracking of protein transport from the ER to lipid droplets
Nov 29, 2023Allison JamesFarnungPredictome screen identifies nucleosome acidic patch interactors
Dec 6, 2023Pruthvi GowdaDanialMechanism and functional consequences of dietary lipids in lineage specification of oncohistone gliomas
Dec 20, 2023Greg BrunettePellmanHaplotype-resolved analysis of chromosome structure and evolution using refLinker
Jan 10, 2024Changqian ZhouWhitmanGCN2 Kinase Activation through Ribosome Collisions: Insights from in vitro Reconstruction of the Amino Acid Response Pathway
Jan 17, 2024Hsin-Yu TsaiLeeTranslational Control of Virus Replication by Ribosome Heterogeneity
Jan 24, 2024Zhikai LiuLiberlesWhy do we get dizzy after standing up? Neural control of cardiovascular response to postural change
Feb 7, 2024Madi CisséManningIntegration of oncogenic signaling and nutrient sensing by mTORC1 in melanoma
Feb 28, 2024Sreeja Jamuna SurendranSubramanianTransporting the Gli transcription factors to the cilium tip compartment for Hedgehog signaling: A tale of two motor systems
Mar 13, 2024Zeyu ChenBernsteinTuning cis-regulatory elements for transcriptional circuit rewiring
Mar 20, 2024Yuxiang ZhengCantleyUnexpected influence of the SWI/SNF-Polycomb axis on methionine metabolism
Mar 27, 2024Tevis VitalePuigserverUtilizing tumor mitochondrial defects to drive anti-tumor immunity
Apr 3, 2024Roberto SotomayerMoazedMechanisms of HP1/Swi6 mediated gene silencing
Apr 10, 2024Pushpa Verma SharmaVan VactorRegulation of innate immune responses by microRNA, miR-980 in Drosophila melanogaster
Apr 17, 2024Simon NoerrelykkeImage Analysis CollaboratoryImage Analysis, Vision Transformers, and LLMs for Cell Biology
Apr 24, 2024Ricardo Bango Da Cunha CorreiaKirchhausenMOSAIC-Lattice Light Sheet with Microfluidics: timing and monitoring the “Action” 
May 1, 2024João CoelhoShaoThe role of ARMC1 at the mitochondrial surface
May 8, 2024Dan ZhaoRapoportInitiation of ERAD by the bifunctional complex of Htm1 mannosidase and protein disulfide isomerase
May 15, 2024Andrii GorelikGygiEnzymatic cysteine modifications: new tools and molecular mechanisms
May 22, 2024Nomeda GirniusBruggeAnalysis of Ovarian Cancer Heterogeneity and Cellular Programs Associated with Chemotherapy Tolerance
May 29, 2025Eva de la SernaCITEMicrotutor: An interactive, online course to learn the fundamentals of optical microscopy
June 5, 2024Sumeet KhetarpalSpiegelmanPGC-1α enables exercise-induced adaptation in the heart through suppression of GDF15 secretion and cardiac atrophy

2022-2023
DATESPEAKERLABTALK TITLE
Sep 7, 2022Mahtab DastpakReedRole of the Essential Splicing Factor SF3B1 in Normal and Neoplastic Hematopoieses
Sep 14, 2022Conor RonaynePuigserverMitochondrial Ribosome Signaling and Survival Mechanisms in Mitochondrial Disease
Sep 28, 2022Anand SaminathanKirchhausenHow Antisense Oligonucleotides Enter Cells
Oct 5, 2022Conghui YaoHaigisUntargeted Metabolomics Reveals Novel Metabolic Markers for T Cell Activation
Oct 26, 2022Yuan GaoRapoportProtein Import into Peroxisomes Occurs Through a Nuclear Pore-like Phase
Nov 2, 2022Kevin DongGygiPhenotypic Screening with Cysteine-targeting Electrophiles to Discover Proteasome
Nov 16, 2022Narek DarabedianChouchaniDevelopment of a First in Class Inhibitor of Creatine Kinases
Nov 30, 2022Sam SedorShaoQuality Control of Orphan Ribosomal Subunit Proteins
Dec 7, 2022Mu ASpiegelmanIrisin Acts Through its Integrin Receptor in a Novel Two-Step Process
Dec 14, 2022Anan ChenSalicExploring the Roles of Double-Membrane Vesicles (DMVs) During Coronavirus Infection
Jan 18, 2023Jon MarkertFarnungCharacterizing H3K36me3 deposition during transcription elongation
Jan 25, 2023Pruthvi GowdaDanialRemodeling lipid metabolism for therapeutic differentiation of oncohistone gliomas
Feb. 15, 2023Stamatis PapathanasiouPellmanMitotic Errors as a novel source of Epigenetic Instability
Feb 22, 2023Kelsey HickeyHarperQuantitative Mapping of the Autophagic Cargo during Nutrient Stress Reveals Membrane Receptors for Golgiphagy
Mar 1, 2023Ngan PhanLeeMechanism of translation repression mediated by elF3
Mar 15, 2023Mike SchappeLiberlesNeural-epithelial coding of airway senses
Mar 29, 2023Yann CormeraisManningDefining in vivo the role of PI3K-mTORC1 signaling in the regulation of systemic glucose metabolism
Apr 5, 2023Alba Rodriguez MeiraBernsteinDeveloping a molecular toolkit to study epigenetic evolution in cancer
Apr 12, 2023Stefan NiekampSubramanianPolycomb repressive complex 1 composition and nucleosomal scaffold properties determine extend of chromatin condensation
Apr 26, 2023Valentina RossioKingDiscovery of new deubiquitylating enzyme substrates in Xenopus egg extract
May 3, 2023Jared JohnsonCantleyIntrinsic substrate specificity of the human protein tyrosine kinome
May 10, 2023Deyang YuPuigserverLysosomal cyst(e)ine regulates melanoma, melanoma dedifferentiation, and ferroptsosis sensitivity
May 17, 2023Juntao YuMoazedDNA replication-coupled parental histone transfer and epigenetic inheritance
June 7, 2023Kumar AavulaVan VactormiRNA mediated regulation of activity induced synaptic plasticity
June 14, 2023Jennifer Waters, Tally Lambert, Federico GasparoliNICOnline tools for learning and performing light microscopy

2021-2022
DATESPEAKERLABTALK TITLE
Sep 15, 2021Zhejian JiRapoport LabTranslocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase
Sep 22, 2021Jiaxin LiangPuigserver LabEndosome Trafficking Defines Mevalonate Pathway Sensitivity in Tumor Resistance
Sep 29, 2021Leila RevolloWhitman LabEstablishing functions for the secreted tyrosine kinase VLK
Oct 20, 2021Jiaming LiGygi LabProteome-wide mapping of short-lived proteins in human cells
Nov 17, 2021Haopeng XiaoChouchani LabArchitecture of the outbred brown fat proteome defines regulators of metabolic physiology
Dec 15, 2021Vincent ChuShao LabSelective destabilization of polypeptides synthesized from NMD-targeted transcripts
Jan 5, 2022Kumar AavulaVan Vactor LabmiRNA mediated regulation of activity induced synaptic plasticity
Jan 12, 2022Bryan SeguinotFinley LabTBCEL-mediated degradation of tubulin during red blood cell differentiation
Jan 19, 2022Melanie MittenbuhlerSpiegelman LabIsolation of interstitial fluids reveals novel secreted bioactive proteins from muscle and fat tissues
Feb 9, 2022Giuseppe Di CaprioKirchhausen LabDeep neural network training for automated identification of intracellular substructures in volumetric electron microscopy
Feb 16, 2022Gengjing ZhaoPellman LabThe Mitotic Actin Cytoskeleton and Endoplasmic Reticulum Morphology Control the Pattern of Nuclear Envelope Assembly
Feb 23, 2022Judy ShenSander LabStudy of combination therapy in ovarian cancer using mass-spectrometry based proteomics
Mar 9, 2022Donghoon LeeGoldberg LabMolecular mechanisms for activation of 26S proteasome and p97 by ZFAND5
Mar 16, 2022Shaoni MukhopadhyayLee LabRegulation of the Epitranscriptome via eIF3d during the Integrated Stress Response (ISR)
Mar 30, 2022Henning Arlt Farese/Walther LabMechanistic insight into lipid droplet biogenesis
Apr 6, 2022Melissa HoyerHarper LabOrganelle quality control in neuronal cells
Apr 13, 2022Aaron HosiosManning LabmTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species
Apr 20, 2022Xiangkun HanBrugge LabNRF2, the master regulator of more than anti-oxidative stress
Apr 27, 2022Accalia FuDanial LabGlucose fuels choice metabolic paths for pancreatic b-cell survival in inflammation
May 11, 2022Haining ZhouMoazed LabNascent RNA Degradation on Chromatin Contributes to Gene Repression
May 18, 2022Farah HaqueSubramanian LabCytoskeletal regulation of a transcription factor by DNA mimicry
May 25, 2022Chen RanLiberles LabOptical deciphering of internal sensory codes in the brain
Jun 1, 2022Peiqing FengRapoport LabThe tale of three RINGS: a heterotrimeric ubiquitin ligase complex forms the peroxisomal retro-translocon
Jun 8, 2022Tomer M. yaronCantley LabThe Kinase Library: A Global Atlas of the Human Protein Kinome

2020-2021
DATESPEAKERLABTALK TITLE
Sep 16, 2020Pushpa SharmaVan Vactor LabmicroRNA, miR-1000 mediated control of metabolism via a novel neuropeptide
Sep 23, 2020Phillip DumesicSpiegelman LabTranslational regulation of PGC1α and oxidative metabolism
Sep 30, 2020Heng ZhaoYuan LabModulating TRADD to restore cellular homeostasis and inhibit apoptosis
Oct 7, 2020Xudong WuRapoport LabMechanism of ERAD-L mediated by the Hrd1 complex
Oct 21, 2020Dylan MitchellGygi LabA Proteome-Wide Map of Drug Mechanism of Action
Oct 28, 2020Mike McKennaShao LabThe P5A-ATPase is a transmembrane helix dislocase
Nov 18, 2020Sharon HungFinley LabModulation of cholesterol metabolism by UBE3B
Dec 9, 2020Navdar SeverRapoport LabMechanism of lamellar body formation by lung surfactant protein B
Dec 16, 2020Brad WierbowskiSalic LabA Molecular Relay for Sending and Receiving Hedgehog Signals (Dissertation in 25 Min)
Jan 13, 2021Ilaria EliaHaigis LabModulating pyruvate fate improves metabolic fitness of CD8+ T cells in tumors
Jan 20, 2021Pedro Latorre-MuroPuigserver LabA cold-inducible PERK/OGT axis controls TOM70-assisted protein import and cristae formation
Jan 27, 2021Ben FramSander LabGenerating Sequence-divergent Proteins Using an Evolution-based Model of Protein Function
Feb 17, 2021Dong Wook ChoiDanial LabMetabolic Fuel Preference and the Excitable Brain
Mar 10, 2021Kenneth GrayBrugge LabThe Protean Lives and Times of the Alveolar Progenitor
Mar 17, 2021Galen CollinsGoldberg LabThe Shuttling Factor & Protease Ddi2 Regulates Protein Degradation and Antigen Presentation
Mar 31, 2021Anita ReddyChouchani LabExamining the Role of Succinate Signaling in Muscle Remodeling Following Exercise
Apr 7, 2021Mitchell LeibowitzPellman LabChromothripsis as an on-target consequence of genome editing
Apr 14, 2021Francois ThelotLiao LabWorking harder, not smarter: wasteful ATP hydrolysis by the lipopolysaccharide floppase MsbA
Apr 21, 2021Jianhua ShiFlanagan LabTau is a novel substrate for Protein Tyrosine Phosphatase σ(PTPσ) -participating in PTPσ mediated neurodevelopment, neural injury and degeneration
Apr 28, 2021Anwesha SanyalKirchhausen LabInhibition of PIKfyve kinase prevents alpha-synuclein aggregation and averts neuronal cell death
May 12, 2021Marito HayashiLiberles LabGut-brain communication mechanisms underlying feeding control
May 19, 2021Tiasha ShafiqMoazed LabDNA-Sequence Dependent Epigenetic Inheritance in Mammalian Cells
May 26, 2021Hankum ParkHarper LabQuantitative proteomics for endo-lysosomal amyloid processing in Alzheimer's disease
Jun 2, 2021Aditi JatkarFarese/Walther LabMechanism underlying the regulation of SREBP-1 activation by glycerolipids

2019-2020
DATESPEAKERLABTALK TITLE
Sep 11, 2019Eduardo Balsa MartinezPuigserver LabDefective NADPH Production in Mitochondrial Disease Complex I Causes Inflammation and Cell Death
Sep 18, 2019Marie BaoDepartments of Cell Biology and BCMPTips on Getting Published: Insights into the Editorial Process
Oct 9, 2019Marcelo CicconetIDACMobile, cloud, assistants, machine learning: analyzing images like it's 2019
Oct 23, 2019Jiuchun ZhangInitiativeCRISPR Services at the Cell Biology Initiative
Oct 30, 2019Mohan ChitrajuFarese/Walther LabLife without fat: insights into energy balance from a novel murine model
Nov 13, 2019Jeeyun ChungFarese/Walther Labthe protein machinery of lipid droplet formation
Nov 20, 2019Maria Del Carmen Fernandez-Aguera RodriguezDanial LabMetabolic Fuel Preference and the Excitable Brain
Dec 4, 2019Reza BehrouziMoazed Labwhat we talk about when we talk about heterochromatin
Dec 18, 2019Erdem SendincShi LabRegulation of gene expression through RNA modifications
Jan 15, 2020Yaara OrenBrugge LabUsing Watermelons to uncover metabolic adaptations of cancer persister cells
Jan 22, 2020Yizhi SunSpiegelman LabFutile Creatine Cycle: Novel Pathway of Thermogenesis
Jan 29, 2020Masanori NaitoYuan LabApoptosis and necroptosis in a disease model
Feb 5, 2020Alban OrdureauHarper LabMolecular Roadmap to PINK1/Parkin Mitophagy Signaling
Feb 19, 2020Valentina RossioKing LabUnmasking functional redundancy of deubiquitylases reveals a prominent role of USP7 in rescuing proteins from degradation
Feb 26, 2020David NusinowGygi LabQuantitative Proteomics of the Cancer Cell Line Encyclopedia
Mar 4, 2020Xuewu SuiLiao LabStructure and catalytic mechanism of a human triacylglycerol synthesis enzyme
Apr 8, 2020GaYoung LeeLiberles LabNot all those who wander are lost: Mechanisms underlying organ-specific targeting by the vagus nerve
Apr 15, 2020Alexandra FranzSander LabBuilding signaling network models using mass spectrometry-based proteomics
Apr 22, 2020Jefte DrijversHaigis LabMetabolic screening identifies ferroptosis as a vulnerability of CD8+ T cells
Apr 29, 2020Neil UmbreitPellman LabMechanisms generating cancer genome complexity from a single cell division error
May 13, 2020Haopeng XiaoChouchani LabA quantitative tissue-specific landscape of protein redox regulation during aging
May 20, 2020Jordan VerplankGoldberg LabRaising cGMP to activate the Ubiquitin Proteasome System and prevent proteotoxic diseases

2018-2019
DATESPEAKERLABTALK TITLE
Sep 12, 2018Jim GouldHarvard Medical SchoolMaking the Most of Your Training Experience at HMS
Sep 19, 2018Zhe ShaGoldberg LabInhibition of ubiquitination causes sumoylation of nuclear proteins
Sep 26, 2018Valentina RossioKing LabProteomic analysis of deubiquitinating enzyme targets and specificity in Xenopus extract
Oct 17, 2018Xing ZengSpiegelman LabInnervation of Thermogenic Adipose Tissue through a Clstn3β/S100b Axis
Oct 24, 2018Ayaz NajafovYuan LabEscape from necroptosis in cancer
Oct 31, 2018Xudong WuRapoport LabStructural basis of ERAD mediated by the Hrd1 ubiquitin ligase complex
Nov 14, 2018Chi LuoPuigserver LabMultifaceted Roles of PGC1a in Melanoma Pathogenesis
Nov 28, 2018Sharan SwarupHarper LabThe retromer complex regulates trafficking of lysosomal proteins
Dec 12, 2018Talley LambertNikon Imaging CenterFPbase.org: a community-editable fluorescent protein database and microscopy resource
Dec 19, 2018Wanqiang ShengShi LabInvestigating the role of LSD1 in tumor immunity and immunotherapy
Jan 9, 2019Jon Van VrankenGygi LabThe role of mitochondrial fatty acid synthesis in supporting cellular respiration
Jan 30, 2019Xuewu SuiFarese/Walther LabCryo-electron microscopy structure of the lipid droplet-formation protein seipin
Feb 6, 2019Yanyan LiLiao LabStructural Snapshots of Lipopolysaccharide Extraction from Bacterial Inner Membrane
Feb 13, 2019Nao HorioLiberles LabThe olfactory circuit of aversive behavior in zebrafish
Feb 20, 2019Dong Wook ChoiDanial LabRegulation of de novo lipogenesis through a glucose sensitive transcriptional complex
Feb 27, 2019Gergana ShipkovenskaMoazed LabEpigenetic inheritance in the fission yeast
Mar 6, 2019Ilja KustersKirchhausen LabReconstitution of clathrin coated pit budding probed by single molecule imaging
Mar 20, 2019Suha Abu AmaraBrugge LabTransient commensalism drives metastasis in a model of ovarian clear cell carcinoma
Mar 27, 2019Mike StifflerSander LabProtein Structure from Laboratory Evolution
Apr 3, 2019Alex WhiteleyFinley LabUsing global proteomics of Ubqln2-mediated mouse models of ALS to reveal client proteins and potential pathways of disease development
Apr 24, 2019Elma ZaganjorHaigis LabThe role of mitochondria in adipogenesis
May 1, 2019I-Ju LeePellman LabNuclear Envelope Sealing: The ESCRT Machinery and More
May 15, 2019Matthew YipShao LabtRNA recycling and quality control from stalled ribosomes
May 22, 2019Jianhua ShiFlanagan LabHSPG inhibits scar formation and promotes axon regeneration and functional recovery after spinal cord injury
Jun 5, 2019Evanna MillsChouchani LabSuccinate accumulation controls activation of adipose tissue thermogenesis
Jun 12, 2019Donghoon LeeGoldberg LabZFAND5 is a novel activator of proteasome and protein degradation
Jun 19, 2019Brandon WoodsVan Vactor LabmiRNA Control of Synaptic Morphogenesis
Jun 26, 2019Ed TwomeyRapoport LabCryo-EM reveals mechanism of substrate processing by the Cdc48 ATPase complex

2017-2018
DATESPEAKERLABTALK TITLE
Sep 13, 2017Amir KargerResearch ComputingHMS Research Computing: Helping CellBio Researchers Do Good (Fast!) Science on Computers
Sep 20, 2017Niklas MejhertFarese/Walther LabGenetic determinants of lipid storage in macrophages
Sep 27, 2017Sara PrescottLiberles LabBuilding a 'Vagal Atlas': Clues to Internal Sensory Systems
Oct 4, 2017Xinmin LiFlanagan LabAxon Guidance at Intermediate Target Through Local Translation
Oct 18, 2017Heeseon AnHarper LabSystematic Analysis of Ribophagy in Human Cells
Oct 25, 2017Nobu TakahashiBrugge LabCancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative Stress Tolerance
Nov 8, 2017Hugo SantosVan Vactor LabUntangled but still tied in knots: from SMA disease model transcriptomes to a SMN-specific gene regulatory network
Nov 15, 2017Bradley WierbowskiSalic LabHow many factors does it take to move a Hedgehog: defining a necessary pathway upstream of ligand reception
Nov 29, 2017Lin DengPellman LabPremature mitotic entry induces genome instability by unloading DNA replicative helicase
Dec 6, 2017Sejal VyasHaigis LabSIRT4 regulation of intestinal homeostasis in the DNA damage response
Dec 13, 2017Gokul UpadhyayulaKirchhausen LabObserving the Cell in Its Native State: Imaging Subcellular Dynamics in Multicellular Organisms
Jan 3, 2018Huibing WangYuan LabPELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP
Jan 10, 2018Nicholas BodnarRapoport LabStructure of the Cdc48 ATPase with its cofactors Ufd1 and Npl4
Jan 24, 2018Seth JohnsonVan Vactor LabDetermining the role of TACC in the development of the synapse in Drosophila
Jan 31, 2018Hyeonwoo "Chad" KimSpiegelman LabIrisin Mediates Beneficial Exercise-induced Effects via Integrins
Feb 7, 2018Eduardo BalsaPuigserver LabER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes Through PERK/eIF2α Axis
Feb 14, 2018Alban OrdureauHarper LabSpatial control of ubiquitin signals underlying mitophagy
Feb 21, 2018Calie FuDanial LabGlucose-dependent partitioning of arginine to urea cycle protects beta cells from inflammation
Feb 28, 2018Kevin JiangHMS Media OfficeScience, News, and You
Mar 14, 2018Michael WeberNikon Imaging CenterNew possibilities for imaging your sample - microscope upgrades in the NIC
Mar 21, 2018Jamie AnastasShi LabTargeting chromatin to induce differentiation in pediatric brain cancer
Mar 28, 2018Mark JedrychowskiGygi LabCharacterizing redox control of thermogenesis
Apr 4, 2018Maja EdeniusWhitman LabCharacterization of a Novel Mammalian Nutritional Stress Response Pathway
Apr 11, 2018Ben OrlandoLiao LabStructure of the Mitochondrial Calcium Uniporter from Cryo-EM and X-ray Crystallography
May 2, 2018Mark CurrieMoazed LabClr4/Suv39h autoregulation prevents illegitimate heterochromatin formation
May 9, 2018Josh Wilson-GradyFinley LabThe Biochemical Program of Extreme Terminal Differentiation
May 16, 2018Alexandra FranzSander LabSystems Biology of Combination Therapy in Ovarian Cancer
May 24, 2018Alison RingelHaigis LabImmunomodulatory mechanisms in the tumor microenvironment
Jun 6, 2018Jordan VerPlankGoldberg LabRaising cGMP enhances protein degradation and proteasome function
Jun 13, 2018Alex KeszeiShao LabProgress towards a structural view of protein triage

2016-2017
DATESPEAKERLABTALK TITLE
Sep 21, 2016Yannis ZervantonakisBrugge LabSystems analysis of signaling pathway adaption after PI3K-pathway inhibition to design effective ovarian cancer combination therapies
Oct 5, 2016Kai HuOlsen LabVEGF-dependent Mechanisms in Bone Repair
Oct 19, 2016Selwin WuPellman LabMechanisms linking centrosome amplification to the senescence associated secretory phenotype in cancer
Oct 26, 2016Wei MiLiao LabcryoEM structures and mechanism of flippase in membrane
Nov 30, 2016Yulu "Cherry" LiuSalic LabHedgehog Signaling in Ciliopathies
Dec 7, 2016Brian CunniffKirchhausen LabMitochondrial positioning by Miro1 supports cell migration and clathrin mediated endocytosis
Dec 14, 2016Yasushi ItoYuan LabRIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS
Jan 4, 2017Robert PowersRapoport LabReconstitution of the tubular endoplasmic reticulum network with purified component
Jan 11, 2017Pushpa Sharma, PhDVan Vactor LabRole of microRNA, miR-980 in immune system of Drosophila melanogaster
Jan 25, 2017Jessica SpinelliHaigis LabMetabolic Recycling of Ammonia Facilitates Breast Cancer Growth and Proliferation
Feb 1, 2017Danial EganSpiegelman LabDecoding PGC1a1 control of Energy Metabolism
Feb 8, 2017Kfir SharabiPuigserver LabSmall Molecule Screen Identifies Selective PGC-1α Gluconeogenic Inhibitors that Ameliorate Diabetic Symptoms
Feb 22, 2017Jin-Mi HeoHarper LabSpatio-temporal mapping of the PINK1-PARKIN mitophagy pathway
Mar 1, 2017Sofia RibeiroDanial LabMetabolic control of neuronal activity by fuel substrate switching: A role for BAD
Mar 15, 2017Talley LambertNikon Imaging CenterLattice Light Sheet Microscopy in the Cell Biology Microscopy Facility
Mar 22, 2017Violetta Karwacki-NeisiusShi LabElucidating the role of the histone demethylase KDM5C in intellectual disability
Mar 29, 2017Julian MintserisGygi LabHigh Density Chemical Cross-linking for Modeling Protein Interactions
Apr 5, 2017Yeonjin KimWhitman LabThe Amino Acid Starvation Response Inhibits Inflammatory Diseases by a Novel Mechanism
Apr 26, 2017Min LuoLiao LabInvader capture in CRISPR - Viewing is believing!
May 10, 2017Xiaoyi WangMoazed LabDNA sequence-dependent epigenetic inheritance of gene silencing and histone H3K9 methylation
May 17, 2017Alexandra GreerFinley LabUbiquilin1 promotes stimulus-dependent proliferation by eliminating mislocalized mitochondrial proteins
May 24, 2017Galen CollinsGoldberg LabAnother Mechanism Regulating the 26S Proteasome: Ubiquitin Life (UbL) Domains Activate Multiple Steps in Conjugate Degradation
May 31, 2017Benjamin SchubertSander LabPopulation-specific design of de-immunized protein biotherapeutics
Jun 7, 2017Haejin YoonHaigis LabAMPK opposes PHD3 to promote fat oxidation through ACC2
Jun 14, 2017Binkai ChiReed LabAnalysis of ALS-causative RNA binding proteins reveals that common factors are shared by motor neuron diseases

2015-2016
DATESPEAKERLABTALK TITLE
Oct 7, 2015Kostadin PetrovSalic LabThe Mechanism of Patched Inhibition by Sonic Hedgehog
Oct 21, 2015Kangmin HeKirchhausen LabDirect probing of dynamic phosphoinositide switches during clathrin-mediated endocytosis
Oct 28, 2015Neil UmbreitPellman LabA new model for chromosome bridge resolution based on nuclear envelope fragility and DNA damage
Nov 18, 2015Su Chiang, Grant Zimmerman and Leandro VetcherOffice of Technology DevlopmentThe Blavatnik Biomedical Accelerator: Supporting Applied Life Sciences at Harvard
Dec 2, 2015Isaac HarrisBrugge LabLooks can be deceiving: the roles of antioxidants in cancer
Dec 16, 2015Julie ChenRapoport LabMechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion
Jan 6, 2016Karina GonzalezHaigis LabIdentifying metabolic vulnerabilities in tumors with low SIRT3
Jan 13, 2016Huajin WangFarese/Walther LabHow Do Lipid Droplets Form From the Endoplasmic Reticulum? - Lessons From Studying The Lipodystrophy Protein Seipin
Jan 27, 2016Ed ChouchaniSpiegelman LabMitochondrial redox control of thermogenic adipose function
Feb 3, 2016Israel Pichardo-CasasVan Vactor LabMuscle maintenance and ALS: a common microRNA theme?
Feb 10, 2016Joeva BarrowPuigserver LabBromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations
Feb 24, 2016Talley LambertNikon Imaging CenterLight sheet microscopy and other new resources in the Cell Biology Microscopy Facility
Mar 2, 2016Long LiRapoport LabCrystal structure of a substrate-engaged SecY protein-translocation channel
Mar 9, 2016Robert LiefkeShi LabTBAGenome-wide modulation of transcription by the PRC2-associated factor C17orf96
Mar 23, 2016Liz LaneDanial LabGlucose sensing and de novo lipogenesis
Mar 30, 2016Laura Pontano-VaitesHarper LabMechanisms of selective autophagy and autophagosome maturation
Apr 6, 2016Su WuNaar LabSREBP1-driven Lipogenesis Pathway in Melanoma
Apr 13, 2016Qian LiLiberles LabNon-canonical amine recognition evolved in a large clade of olfactory receptors
Apr 20, 2016Leila RevolloWhitman LabThe role of VLK in the dynamics of extracellular matrix
May 4, 2016Jiefei GengYuan LabTAK1-mediated RIPK1 phosphorylation negatively regulates RIPK1-dependent apoptosis
May 11, 2016Gloria JihMoazed LabRNAi@chromatin.pombe (Pizza Emoji) (Pizza Emoji) #H3K9methylation #genesilencing
May 18, 2016Stefanie De PootFinley LabUnraveling the function of the proteasomal deubiquitinating enzyme UCH37
May 25, 2016Chueh-Ling KuoGoldberg LabUbiquitin conjugates promote the association of Usp14 and Ube3c with proteasomes

2014-2015
DATESPEAKERLABTALK TITLE
Sep 24, 2014Pengxiang HuangSalic LabActivation of Hedgehog Signaling by Sterol-Triggered Conformational Switch in Smoothened
Oct 1, 2014Frances EvessonKirchhausen LabDysferlin to the rescue! Membrane repair in skeletal muscle cells
Oct 8, 2014Hugo Arellano-SantoyoPellman LabTowards an understanding of the molecular mechanism of the unique biomechanical properties of the yeast kinesin-8 Kip3
Oct 22, 2014Shanye YinReed LabFunctional coupling of RNAP II transcription to pri-miRNA processing
Oct 29, 2014Noga Ron-HarelHaigis LabA Synchronized Program of Mitochondrial Remodeling and Fuel Metabolism Supports Naïve T cell Activation
Nov 5, 2014Lisa GallegosBrugge Lab 
Nov 12, 2014Fabian Romano-ChernacRapoport Lab 
Nov 19, 2014Nora KoryFarese & Walther Lab 
Dec 3, 2014Romain ChristianoFarese & Walther Lab 
Jan 21, 2015Kfir SharabiPuigserver Lab 
Feb 4, 2015Lawrence KazakSpiegelman Lab 
Feb 18, 2015Zhe ShaGoldberg Lab 
Feb 19, 2015Accalia FuDanial Lab 
Mar 4, 2015Wei HuangOlsen Lab 
Mar 11, 2015Benoit LaurentShi Lab 
Mar 18, 2015Xinmin LiFlanagan Lab 
Apr 8, 2015Christian MunchHarper Lab 
Apr 15, 2015Hongguang XiaYuan Lab 
Apr 29, 2015Ryan BaldridgeRapoport LabExploring ERAD retro-translocation using a reconstituted system
May 6, 2015Talley LambertNikon Imaging CenterFirst impressions and optimization of 3D-structured illumination microscopy on the OMX Blaze
May 13, 2015Rui ChangLiberles LabVagal sensory neuron subtypes that differentially control breathing
May 27, 2015Miguel PradoFinley LabRemodeling of the proteome by USP14
Jun 3, 2015Alexandre WagschalNaar LabGenome-wide identification of microRNAs regulating cholesterol/lipid homeostasis
Jun 10, 2015Kaushik RagunathanMoazed LabHow cells create and maintain memories of gene expression

2013-2014
DATESPEAKERLABTALK TITLE
Sep 25, 2013Marcin IwanickiBrugge LabTargeting Mutant p53 and Cell-Cell Adhesion in Ovarian Cancer
Oct 2, 2013Xiaoxiao GuBlenis LabIntegration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis (LAM) pathogenesis
Oct 9, 2013W. Bret RedwineReck-Peterson LabThe mystery of processivity: towards an understanding of the basis of motor properties in vivo
Oct 30, 2013Jennifer LongVan Vactor LabThe role of microtubule dynamics during nervous system development
Nov 6, 2013Ruby YuMoazed LabIdentification of locus features that permit targeting by RNAi-mediated heterochromatin in fission yeast
Nov 13, 2013Kwonmoo LeeDanuser LabMechanosensitivity in the Cooperative Dynamics of Actin Nucleators During Epithelial Cell Protrusion
Dec 4, 2013Helin NorbergYuan LabIdentification of a novel Degradation Pathway for Mutant p53
Dec 11, 2013Yong YuReed LabU1 snRNP and FUS in coupling transcription to pre-mRNA splicing
Jan 15, 2014Benedikt BauerRapoport LabElucidating the molecular mechanism of protein translocation by the SecA-ATPase
Jan 29, 2014Nikolay KukushkinGoldberg LabProteasome autoubiquitination regulates its function
Feb 5, 2014Daniel NedelcuSalic LabRegulation of Smoothened in the Hedgehog Pathway
Feb 12, 2014Seung Min JeongHaigis LabRegulation of metabolic response to DNA damage by SIRT4
Feb 26, 2014Michael WeekesGygi LabQuantitative Temporal Viromics: a new approach to investigate host-pathogen interaction
Mar 5, 2014Yoonjin LeePuigserver LabCyclin D1-CDK4 controls glucose metabolism independently of cell cycle progression
Mar 12, 2014Maude BaldwinLiberles LabEvolution of sweet taste perception in a nectar-feeding bird
Mar 26, 2014Po-Lin ChiuWalz LabStructural studies of lipid-protein interactions by using two-dimensional crystals of aquaporin-0
Apr 2, 2014Melissa HancockFlanagan LabRole of miRNA in axon development
Apr 9, 2014Illana StanleyDanial LabMetabolic Heterogeneity in Molecular Subsets of Diffuse Large B-Cell Lymphoma
Apr 30, 2014Mijung KwonPellman LabHow cancer cells divide with too many centrosomes: the Achilles’ heel of cancer cells
May 1, 2014Alex SteinRapoport Lab 
May 7, 2014Anne WhiteHarper LabQuantitative analysis of the Hippo pathway in low and high-density cells
May 14, 2014Andres BlancoShi LabRNAi screens for epigenetic regulators of differentiation in Acute Myeloid Leukemia

2012-2013
DATESPEAKERLABTALK TITLE
Jan 9, 2013Alexis LomakinDanuser LabMyosin-II serves as global inhibitor of self-organizing polarity in immotile cells
Feb 6, 2013Anthony NguyenFinley LabUbiquitination in Erythropoiesis and the Pathophysiology of Anemias
Feb 13, 2013Gaelle LaurentHaigis LabSIRT4 controls the balance between lipid synthesis and catabolism by repressing malonyl-CoA Decarboxylase
Feb 26, 2013Michael WeekesGygi Lab 
Mar 6, 2013Rebecca MathewMoazed LabStoring memories: the role of miR-153 in long-term memory formation
Mar 13, 2013Grant ZimmermannBrugge Lab 
Apr 10, 2013Neil GanemPellman LabTetraploidy, Aneuploidy,and Cancer
Jun 5, 2013Dongyan TanWalz LabStructural and functional studies on the tethering complex TRAPPIII
Jun 12, 2013Elizabeth McNeilVan Vactor LabTools to define microRNA regulatory complexity in Drosophila