Brugge lab generates a multi-dimensional atlas of human breast tissue

Image of the summary of the single-cell technologies to establish a human breast cell atlas.

In this study led by Kenneth Gray, Carman Li, Jennifer Rosenbluth, and Laura Selfors in the Brugge Lab, the group, together with many collaborators within HMS and outside,   generated a multi-dimensional atlas of human breast tissues and organoids. They found distinct epithelial cell subtypes to be associated with various clinical variables, such as age, parity, and gremline BRCA2 mutation. In particular, an alveolar subset, which they termed basal-luminal cells, were found to display poor transcriptional lineage fidelity and gene expression signatures associated with aggressive basal-like breast cancers.

Read the full paper here.